X6REB3 · X6REB3_HUMAN

  • Protein
    Transcription factor E2-alpha
  • Gene
    TCF3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Molecular FunctionDNA binding
Molecular Functionprotein dimerization activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor E2-alpha
  • Alternative names
    • Transcription factor 3

Gene names

    • Name
      TCF3

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    X6REB3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,152 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)12PRIDEPhosphothreonine
Modified residue (large scale data)39PRIDEPhosphoserine
Modified residue (large scale data)168PRIDEPhosphoserine
Modified residue (large scale data)170PRIDEPhosphoserine
Modified residue (large scale data)183PRIDEPhosphoserine
Modified residue (large scale data)185PRIDEPhosphoserine
Modified residue (large scale data)186PRIDEPhosphoserine
Modified residue (large scale data)217PRIDEPhosphoserine
Modified residue (large scale data)234PRIDEPhosphothreonine
Modified residue (large scale data)274PRIDEPhosphoserine
Modified residue (large scale data)357PRIDEPhosphoserine
Modified residue (large scale data)380PRIDEPhosphoserine
Modified residue (large scale data)383PRIDEPhosphoserine
Modified residue (large scale data)384PRIDEPhosphothreonine
Modified residue (large scale data)388PRIDEPhosphoserine
Modified residue (large scale data)408PRIDEPhosphoserine
Modified residue (large scale data)410PRIDEPhosphoserine
Modified residue (large scale data)538PRIDEPhosphoserine
Modified residue (large scale data)543PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region36-90Disordered
Compositional bias54-90Polar residues
Region164-234Disordered
Compositional bias168-192Polar residues
Region269-297Disordered
Compositional bias321-356Polar residues
Region321-358Disordered
Compositional bias372-395Polar residues
Region372-414Disordered
Region490-563Disordered
Compositional bias523-563Basic and acidic residues
Domain574-627BHLH
Region658-679Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    679
  • Mass (Da)
    70,075
  • Last updated
    2014-10-29 v2
  • Checksum
    A64B0EF1626FA35E
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGECLAWCGPSAVHRCADVGLGMVSARTAPGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSTDEVLSLEEKDLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM

Computationally mapped potential isoform sequences

There are 14 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P15923TFE2_HUMANTCF3654
A0A0A0MTS0A0A0A0MTS0_HUMANTCF3159
A0A494C1R3A0A494C1R3_HUMANTCF3139
K7EKB9K7EKB9_HUMANTCF3179
K7EK65K7EK65_HUMANTCF382
K7EJN4K7EJN4_HUMANTCF351
K7ELF3K7ELF3_HUMANTCF3151
K7EMM4K7EMM4_HUMANTCF3220
K7ENH8K7ENH8_HUMANTCF3314
K7ENI0K7ENI0_HUMANTCF395
K7EPS2K7EPS2_HUMANTCF3165
K7EPH6K7EPH6_HUMANTCF396
K7ERZ7K7ERZ7_HUMANTCF3204
A0A994J7B2A0A994J7B2_HUMANTCF3132

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias54-90Polar residues
Compositional bias168-192Polar residues
Compositional bias321-356Polar residues
Compositional bias372-395Polar residues
Compositional bias523-563Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC005321
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC006274
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KC877695
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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