X6REB3 · X6REB3_HUMAN
- ProteinTranscription factor E2-alpha
- GeneTCF3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids679 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleoplasm | |
Molecular Function | DNA binding | |
Molecular Function | protein dimerization activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTranscription factor E2-alpha
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionX6REB3
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,152 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 12 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 39 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 168 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 170 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 183 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 185 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 186 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 217 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 234 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 274 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 357 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 380 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 383 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 384 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 388 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 408 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 410 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 538 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 543 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 36-90 | Disordered | ||||
Sequence: RPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS | ||||||
Compositional bias | 54-90 | Polar residues | ||||
Sequence: PSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS | ||||||
Region | 164-234 | Disordered | ||||
Sequence: PGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKT | ||||||
Compositional bias | 168-192 | Polar residues | ||||
Sequence: SPSGMKGTSQYYPSYSGSSRRRAAD | ||||||
Region | 269-297 | Disordered | ||||
Sequence: LGGGSSPLPLPPGSGPVGSSGSSSTFGGL | ||||||
Compositional bias | 321-356 | Polar residues | ||||
Sequence: SFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGS | ||||||
Region | 321-358 | Disordered | ||||
Sequence: SFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSG | ||||||
Compositional bias | 372-395 | Polar residues | ||||
Sequence: DHSSNNFSSSPSTPVGSPQGLAGT | ||||||
Region | 372-414 | Disordered | ||||
Sequence: DHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGG | ||||||
Region | 490-563 | Disordered | ||||
Sequence: NHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSTDEVL | ||||||
Compositional bias | 523-563 | Basic and acidic residues | ||||
Sequence: ASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSTDEVL | ||||||
Domain | 574-627 | BHLH | ||||
Sequence: ERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGL | ||||||
Region | 658-679 | Disordered | ||||
Sequence: PQMVLSAPHPGLSEAHNPAGHM |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length679
- Mass (Da)70,075
- Last updated2014-10-29 v2
- ChecksumA64B0EF1626FA35E
Computationally mapped potential isoform sequences
There are 14 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P15923 | TFE2_HUMAN | TCF3 | 654 | ||
A0A0A0MTS0 | A0A0A0MTS0_HUMAN | TCF3 | 159 | ||
A0A494C1R3 | A0A494C1R3_HUMAN | TCF3 | 139 | ||
K7EKB9 | K7EKB9_HUMAN | TCF3 | 179 | ||
K7EK65 | K7EK65_HUMAN | TCF3 | 82 | ||
K7EJN4 | K7EJN4_HUMAN | TCF3 | 51 | ||
K7ELF3 | K7ELF3_HUMAN | TCF3 | 151 | ||
K7EMM4 | K7EMM4_HUMAN | TCF3 | 220 | ||
K7ENH8 | K7ENH8_HUMAN | TCF3 | 314 | ||
K7ENI0 | K7ENI0_HUMAN | TCF3 | 95 | ||
K7EPS2 | K7EPS2_HUMAN | TCF3 | 165 | ||
K7EPH6 | K7EPH6_HUMAN | TCF3 | 96 | ||
K7ERZ7 | K7ERZ7_HUMAN | TCF3 | 204 | ||
A0A994J7B2 | A0A994J7B2_HUMAN | TCF3 | 132 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 54-90 | Polar residues | ||||
Sequence: PSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS | ||||||
Compositional bias | 168-192 | Polar residues | ||||
Sequence: SPSGMKGTSQYYPSYSGSSRRRAAD | ||||||
Compositional bias | 321-356 | Polar residues | ||||
Sequence: SFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGS | ||||||
Compositional bias | 372-395 | Polar residues | ||||
Sequence: DHSSNNFSSSPSTPVGSPQGLAGT | ||||||
Compositional bias | 523-563 | Basic and acidic residues | ||||
Sequence: ASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSTDEVL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC005321 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC006274 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KC877695 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |