X6RBG4 · X6RBG4_HUMAN

  • Protein
    Uromodulin
  • Gene
    UMOD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentciliary membrane
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular space
Cellular Componentside of membrane
Molecular Functioncalcium ion binding
Biological Processapoptotic signaling pathway
Biological Processautophagy
Biological Processcellular response to unfolded protein
Biological Processchaperone-mediated protein folding
Biological Processcitric acid secretion
Biological Processcollecting duct development
Biological Processconnective tissue replacement
Biological Processdefense response to Gram-negative bacterium
Biological Processendoplasmic reticulum organization
Biological ProcessERAD pathway
Biological Processglomerular filtration
Biological Processinflammatory response
Biological Processinnate immune response
Biological Processintracellular calcium ion homeostasis
Biological Processintracellular chloride ion homeostasis
Biological Processintracellular phosphate ion homeostasis
Biological Processintracellular sodium ion homeostasis
Biological Processjuxtaglomerular apparatus development
Biological Processlipid metabolic process
Biological Processmetanephric ascending thin limb development
Biological Processmetanephric distal convoluted tubule development
Biological Processmetanephric thick ascending limb development
Biological Processmicturition
Biological Processmulticellular organismal response to stress
Biological Processorgan or tissue specific immune response
Biological Processpotassium ion homeostasis
Biological Processprotein localization to vacuole
Biological Processprotein transport into plasma membrane raft
Biological Processregulation of blood pressure
Biological Processregulation of protein transport
Biological Processregulation of urine volume
Biological Processrenal sodium ion absorption
Biological Processrenal urate salt excretion
Biological Processrenal water homeostasis
Biological Processresponse to lipopolysaccharide
Biological Processresponse to water deprivation
Biological Processresponse to xenobiotic stimulus
Biological ProcessRNA splicing
Biological Processtumor necrosis factor-mediated signaling pathway
Biological Processurate transport
Biological Processurea transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Uromodulin

Gene names

    • Name
      UMOD

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    X6RBG4

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Lipid-anchor, GPI-anchor
Basolateral cell membrane
; Lipid-anchor, GPI-anchor
Secreted

Keywords

Disease & Variants

Variants

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The viewer provides 993 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer that then polymerizes into long filaments. The filaments can additionally assemble laterally to form a sheet. The filaments consist of a zigzag-shaped backbone with laterally protruding arms which interact with bacterial adhesin fimH. Two fimH molecules can bind to a single UMOD monomer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain77-113EGF-like
Domain114-156EGF-like
Domain157-198EGF-like
Domain383-638ZP

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    689
  • Mass (Da)
    75,663
  • Last updated
    2014-06-11 v1
  • Checksum
    0737F04924095FA0
MRHIMTRLTLPFWLQDTRHQRQREKFKGPTRLSFGQVLSRPEVAGRAERMGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P07911UROM_HUMANUMOD640
Q8NHW8Q8NHW8_HUMANUMOD29
I3L4Y6I3L4Y6_HUMANUMOD102
I3L4B0I3L4B0_HUMANUMOD86
I3L3Z4I3L3Z4_HUMANUMOD161
I3L3E0I3L3E0_HUMANUMOD161
I3L2J2I3L2J2_HUMANUMOD88
I3L2K2I3L2K2_HUMANUMOD110
I3L1M3I3L1M3_HUMANUMOD125

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC106796
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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