X5DNX5 · X5DNX5_HUMAN
- ProteinPhosphodiesterase
- GenePDE4B
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids736 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Pathway
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 406 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 406-410 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNSLH | ||||||
Binding site | 410 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 446 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 447 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 447 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 447 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 564 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 564 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 615 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionX5DNX5
Organism-specific databases
Disease & Variants
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 51-78 | Disordered | ||||
Sequence: QLPPLSQRQSERARTPEGDGISRPTTLP | ||||||
Region | 189-209 | Disordered | ||||
Sequence: LHGTSNKRSPAASQPPVSRVN | ||||||
Region | 282-301 | Disordered | ||||
Sequence: KQNDVEIPSPTQKDREKKKK | ||||||
Domain | 330-659 | PDEase | ||||
Sequence: VNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQS | ||||||
Region | 685-736 | Disordered | ||||
Sequence: DEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT | ||||||
Compositional bias | 716-736 | Basic and acidic residues | ||||
Sequence: RDSLGETDIDIATEDKSPVDT |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length736
- Mass (Da)83,343
- Last updated2014-06-11 v1
- Checksum208FCE9CD40EF5EB
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 716-736 | Basic and acidic residues | ||||
Sequence: RDSLGETDIDIATEDKSPVDT | ||||||
Non-terminal residue | 736 | |||||
Sequence: T |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KJ534916 EMBL· GenBank· DDBJ | AHW56556.1 EMBL· GenBank· DDBJ | mRNA |