X5DNM4 · X5DNM4_HUMAN

  • Protein
    Lactoylglutathione lyase
  • Gene
    GLO1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site34Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site34substrate; ligand shared between dimeric partners
Binding site38substrate; ligand shared between dimeric partners
Binding site100Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site104substrate; ligand shared between dimeric partners
Binding site123substrate; ligand shared between dimeric partners; in other chain
Binding site127Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site127substrate; ligand shared between dimeric partners; in other chain
Binding site157-158substrate; ligand shared between dimeric partners; in other chain
Active site173Proton donor/acceptor
Binding site173Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentplasma membrane
Molecular Functionlactoylglutathione lyase activity
Molecular Functionzinc ion binding
Biological Processglutathione metabolic process
Biological Processmethylglyoxal metabolic process
Biological Processosteoclast differentiation
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lactoylglutathione lyase
  • EC number
  • Alternative names
    • Glyoxalase I

Gene names

    • Name
      GLO1
    • ORF names
      hCG_32350

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    X5DNM4

Organism-specific databases

Subcellular Location

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-177VOC

Sequence similarities

Belongs to the glyoxalase I family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    184
  • Mass (Da)
    20,778
  • Last updated
    2014-06-11 v1
  • Checksum
    46291B7878070028
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue184

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ534846
EMBL· GenBank· DDBJ
AHW56486.1
EMBL· GenBank· DDBJ
mRNA
CH471081
EMBL· GenBank· DDBJ
EAX03964.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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