X5CPA9 · X5CPA9_9RHAB

Function

function

RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.

Catalytic activity

  • GTP + H2O = GDP + phosphate + H+
  • a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H+
    EC:2.1.1.375 (UniProtKB | ENZYME | Rhea)
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine + H+
  • a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H+ = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
    EC:2.7.7.88 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular FunctionRNA-dependent RNA polymerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      L

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JX09-18
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Rhabdoviridae > Alpharhabdovirinae > Lyssavirus

Accessions

  • Primary accession
    X5CPA9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

May form homodimer. Interacts with the P protein.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-31Disordered
Domain612-800RdRp catalytic
Domain1675-1872Mononegavirus-type SAM-dependent 2'-O-MTase

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,128
  • Mass (Da)
    242,700
  • Last updated
    2014-06-11 v1
  • Checksum
    D270A7D654C72B0F
MMIDPGEVYDDPVDPIESEAEPRGTPTVPNILRNSDYNLNSPLIEDPAKLMLEWLKTGNRPYRMTLTDNCSRSYKVLKDYFKKLDLGSLKVGGTAAQSMISLWLYGAHSESNRSRKCMTDLAHFYSKSSPIEKLLNCTLGNRGLRIPPEGVLSCLERVDYDKAFGRYLANTYSSYLFFHVITLYMNALDWDEEKTILALWRDLTSVDVGKDLVKFKDQIWGLLIVTKDFVYSQSSNCLFDRNYTLMLKDLFLSRLNSLMILLSPPEPRYSDGLISQLCQLYIAGDQVLSMCGNSGYEVIKILEPYVVNSLVQRAEKFRPLIHSLGDFPVFIEDKVSQLEGTFGPSAKRFFRVLDQFDNIQDLVFVYGCYRHWGHPYIDYRKGLSKLYDQVHIKKVIDKSYQECLASDLARRILRWGFDKYSKWYIDSRLLPRDHPLTPYIKTQTWPPKHVVDLVGDAWHKLPITQIFEIPESMDPSEILDDKSHSFTRTRLASWLSENRGGPVPSEKVIITALSKPPVNPREFLKSIDLGGLPDEDLIIGLKPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDRVTGQGLLDYSRVTYAFHLDYEKWNNHQRLESTEDVFSVLDQVFGLKRVFSRTHEFFQKSWIYYSDRSDLIGLWEDQIYCLDMSDGPTCWNGQDGGLEGLRQKGWSPVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSPGLSREGLLYELESISRNALSIYRAIEEGAAKLGLIIKKEETMCSYDFLIYGKTPLFRGNILVPESKRWARVSCISNDQIVNLANIMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILNAEGDNFLIAMSRIIYLDPSLGGVSGMSLGRFHIRQFSDPVSEGLSFWREIWLSSHESWIHALCQEAGNPDLGERTLESFTRLLEDPTTLNIKGGASPTILLKDAIRKALYDEVDKVENSEFREAILLSKTHRDNFILFLKSVEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRKSLSRTLEESFYNSEIHGINRMTQTPQRVGRVWTCSSERADLLREISWGRKVVGTTVPHPSEMLGLLPKSSISCTCGATGGGNPRVSVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRALSLKESINWFITRNSNLAQTLIRNIMSLTGPDFPIGEPPAFKRTGSALHRFKSARYSEGGYSSVCPNLLSHISVSTDTMSDLTQDGKNYDFMFQPLMLYAQTWTSELVQRDTRLKDSTFHWHLRCNRCVRPIDDITLETSQIFEFPDVSKRISRMVSGAVPHFQRLPDIRLKPGDFESLSGKEKSRHIGSAQGLLYSILVAIHDSGYNDGTIFPVNIYSKVSPRDYLRGLARGILIGSSICFLTRVTNININRPLELISGVISYILLRLDNHPSLYIMLREPSLRGEIFSIPQKIPAAYPTTMKEGNRSILCYLQHVLRYEREVITASPENDWLWIFSDFRSSKMTYLTLITYQSHLLLQRIERNLSKSMRANLRQMSSLMRQVLGGHGEDTLESNDDIQRLLKDSLRRTRWVDQEVRHAARTMTGDYSPNKKMSRKAGCSEWVCSAQQVAVSTSANPAPVSELDIRALSKRFQNPLISGLRVVQWATGAHYKLKPILDDLNVFPSLCLVVGDGSGGISRAVLNMFPDAKLVFNSLLEVNDLMASGTHPLPPSAIMSGGDEIVSRVIDFDSIWEKPSDLRNLTTWKYFQSVQKKVNMSYDLIICDAEVTDIASINRITLLMSDFALSIDGPLYLVLKTYGTMLVNPEYRAIQHLSRAFPSVTGFITQMTSSFSSELYLRFSKRGKFFRDAEYLTSSTLREMSLVLFNCSSPKSEMQRARSLNYQDLVRGFPEEIISNPYNEMIITLIDSDVESFLVHKMVDDLELQRGTLSKMSIIIAIMIVFSNRVFNVSKPLTDPLFYPPSDPKILRHFNICCSTMMYLATALGDVPSFARLHDLYNRPITYYFKKQVIRGSVYLSWSWSDDTSVFKRVACNSSLSLSSHWIRLIYKIVKTTRLIGSIDRSSGEVVRHLQGYNRWITLEDVKSRSSLLDYSCL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF726852
EMBL· GenBank· DDBJ
AHW49164.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

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