X2JGR4 · X2JGR4_DROME
- Proteinnon-specific protein-tyrosine kinase
- GeneAbl
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1620 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for X2JGR4
Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
Cited inMapped toBMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis.
- AnnotationBMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0000017, GeneRif: 45821
Tyrosine phosphorylation and proteolytic cleavage of Notch are required for non-canonical Notch/Abl signaling in <i>Drosophila</i> axon guidance.
- AnnotationNotch-Abl axonal signaling requires proteolytic cleavage events that initiate canonical Notch signaling. Some Notch protein is tyrosine phosphorylated this form of the protein is selectively associated with Disabled and Trio and relevant tyrosines are essential for Notch-dependent axon patterning but not for canonical Notch-dependent regulation of cell fate.
- CategoriesFunction, PTM / Processing, Interaction
- SourceGeneRif: 45821
Different modes of APC/C activation control growth and neuron-glia interaction in the developing <i>Drosophila</i> eye.
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0000017
Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes.
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0000017
The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization.
- CategoriesFunction, Interaction, Subcellular Location
- SourceFlyBase: FBgn0000017
Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm.
- Annotationin addition to its role as a transcription factor Eya functions as a cytoplasmic protein tyrosine phosphatase
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0000017, GeneRif: 45821
Dscam guides embryonic axons by Netrin-dependent and -independent functions.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells.
- AnnotationThese findings suggest that the reciprocal regulation of Abi phosphorylation by Abl and PTP61F may regulate the localization and stability of Abi and may regulate the formation of lamella.
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0000017, GeneRif: 45821
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain.
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0000017
Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1.
- Annotationa reduction in Abl gene dosage causes distal paralysis and axonal swellings
- CategoriesInteraction
- SourceFlyBase: FBgn0000017, GeneRif: 45821
The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
Abi enhances Abl-mediated CDC2 phosphorylation and inactivation.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
GAPs in Slit-Robo signaling.
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0000017
Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance.
- CategoriesFunction, PTM / Processing, Interaction
- SourceFlyBase: FBgn0000017
Functions of WW domains in the nucleus.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017
Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity.
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0000017
Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled.
- CategoriesInteraction
- SourceFlyBase: FBgn0000017