X2FCN7 · X2FCN7_CHV16
- ProteinCytoplasmic envelopment protein 3
- GeneUL11
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell Golgi membrane | |
Cellular Component | host cell plasma membrane | |
Cellular Component | membrane | |
Cellular Component | viral tegument | |
Cellular Component | virion membrane | |
Biological Process | anatomical structure morphogenesis | |
Biological Process | viral budding from Golgi membrane |
Names & Taxonomy
Protein names
- Recommended nameCytoplasmic envelopment protein 3
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus papiinealpha2
- Virus hosts
Accessions
- Primary accessionX2FCN7
Subcellular Location
UniProt Annotation
GO Annotation
Virion membrane ; Lipid-anchor
Host cell membrane ; Lipid-anchor
Host Golgi apparatus membrane ; Lipid-anchor
Note: Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, lipidation, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed; by host | |||
Lipidation | 2 | N-myristoyl glycine; by host | |||
Modified residue | 40 | Phosphoserine | |||
Post-translational modification
Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.
Keywords
- PTM
Interaction
Subunit
Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.
Structure
Family & Domains
Features
Showing features for motif, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 18-19 | Di-leucine-like internalization motif | |||
Region | 37-43 | Asp/Glu-rich (acidic) | |||
Region | 56-95 | Disordered | |||
Compositional bias | 68-82 | Basic and acidic residues | |||
Sequence similarities
Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length95
- Mass (Da)10,316
- Last updated2014-06-11 v1
- ChecksumBB96234388837752
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 68-82 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF908240 EMBL· GenBank· DDBJ | AHM96059.1 EMBL· GenBank· DDBJ | Genomic DNA |