X2FCN7 · X2FCN7_CHV16

Function

function

Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.

GO annotations

AspectTerm
Cellular Componenthost cell Golgi membrane
Cellular Componenthost cell plasma membrane
Cellular Componentmembrane
Cellular Componentviral tegument
Cellular Componentvirion membrane
Biological Processanatomical structure morphogenesis
Biological Processviral budding from Golgi membrane

Names & Taxonomy

Protein names

  • Recommended name
    Cytoplasmic envelopment protein 3

Gene names

    • Name
      UL11

Organism names

Accessions

  • Primary accession
    X2FCN7

Subcellular Location

Virion tegument
Virion membrane
; Lipid-anchor
Host cell membrane
; Lipid-anchor
Host Golgi apparatus membrane
; Lipid-anchor
Note: Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).

Keywords

PTM/Processing

Features

Showing features for initiator methionine, lipidation, modified residue.

Type
IDPosition(s)Description
Initiator methionine1Removed; by host
Lipidation2N-myristoyl glycine; by host
Modified residue40Phosphoserine

Post-translational modification

Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.

Keywords

Interaction

Subunit

Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.

Family & Domains

Features

Showing features for motif, region, compositional bias.

Type
IDPosition(s)Description
Motif18-19Di-leucine-like internalization motif
Region37-43Asp/Glu-rich (acidic)
Region56-95Disordered
Compositional bias68-82Basic and acidic residues

Sequence similarities

Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    95
  • Mass (Da)
    10,316
  • Last updated
    2014-06-11 v1
  • Checksum
    BB96234388837752
MGLTGSRVGPCCCRRNVLVTDRGETVSLTANEFDAVELESDAGGNFYISPELRVVTQPPAQAPHPRGPPSRGDRHWSRGGRHPDHISYPTPPAVR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias68-82Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF908240
EMBL· GenBank· DDBJ
AHM96059.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help