X2CJK9 · X2CJK9_EPICO

Function

function

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site205ATP (UniProtKB | ChEBI)
Binding site206ATP (UniProtKB | ChEBI)
Active site303Proton acceptor
Binding site305ATP (UniProtKB | ChEBI)
Binding site305-307ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-phosphoinositide-dependent protein kinase activity
Molecular FunctionAMP-activated protein kinase activity
Molecular FunctionATP binding
Molecular FunctionDNA-dependent protein kinase activity
Molecular Functioneukaryotic translation initiation factor 2alpha kinase activity
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionhistone H2AS121 kinase activity
Molecular Functionhistone H2AT120 kinase activity
Molecular Functionhistone H2AXS139 kinase activity
Molecular Functionhistone H2BS14 kinase activity
Molecular Functionhistone H2BS36 kinase activity
Molecular Functionhistone H3S10 kinase activity
Molecular Functionhistone H3S28 kinase activity
Molecular Functionhistone H3S57 kinase activity
Molecular Functionhistone H3T11 kinase activity
Molecular Functionhistone H3T3 kinase activity
Molecular Functionhistone H3T45 kinase activity
Molecular Functionhistone H3T6 kinase activity
Molecular Functionhistone H4S1 kinase activity
Molecular Functionmagnesium ion binding
Molecular FunctionRho-dependent protein serine/threonine kinase activity
Molecular Functionribosomal protein S6 kinase activity
Biological Processinnate immune response
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin-1 receptor-associated kinase 4
  • EC number

Organism names

Accessions

  • Primary accession
    X2CJK9

Subcellular Location

Keywords

Interaction

Subunit

Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.

Structure

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region108-146Disordered
Domain178-453Protein kinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    464
  • Mass (Da)
    51,706
  • Last updated
    2014-06-11 v1
  • MD5 Checksum
    1D4A0FF3F2D3D696994BDE3C35619C67
MNNSVTSATYIRRLSYSSLRKLSDFLDPQDRWKDVIVSIRKPNGELRYSQHHVRRFEGVVAQGKSPTVELLADWGTSNSTVGELVDILRSHKLLAAASVLLPVEEAATPVRQPASPPAAEPNSSLPTRLVGETKTQPPADSPDLQPQILLESSEPGFSSFLYNELMKITGNFDDRPISDGGCRIGEGGFGTVYRGLLNDKPVAVKKLNAMEDVSLDELRVQFNQEIQTLQVLKHENLVDMVGFSSDGQHPCLVYDLMANGSLLDRLACLEGSPPLSWRRRCLIAEGTAIGLEYLHSNHHVHRDVKSANILLDAEFVAKISDFGLTRASAKRTSTTMMTERVVGTRAYMAPEALRGEITPKSDVFSFGVVLLEILSGLRPADENREPQFLMEMRYDIDDEDEELTLEDFLDKKMSDWELSQVESIYSLASNCLHDRKNRRPVIKQVLLELKGVVKSISLDVEAQE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX856139
EMBL· GenBank· DDBJ
AGQ48127.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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