X2CJK9 · X2CJK9_EPICO
- ProteinInterleukin-1 receptor-associated kinase 4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids464 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 205 | ATP (UniProtKB | ChEBI) | |||
Binding site | 206 | ATP (UniProtKB | ChEBI) | |||
Active site | 303 | Proton acceptor | |||
Binding site | 305 | ATP (UniProtKB | ChEBI) | |||
Binding site | 305-307 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInterleukin-1 receptor-associated kinase 4
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Serranoidei > Serranidae > Epinephelinae > Epinephelini > Epinephelus
Accessions
- Primary accessionX2CJK9
Subcellular Location
Interaction
Subunit
Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 108-146 | Disordered | |||
Domain | 178-453 | Protein kinase | |||
Sequence similarities
Family and domain databases
Sequence
- Sequence statusComplete
- Length464
- Mass (Da)51,706
- Last updated2014-06-11 v1
- MD5 Checksum1D4A0FF3F2D3D696994BDE3C35619C67
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JX856139 EMBL· GenBank· DDBJ | AGQ48127.1 EMBL· GenBank· DDBJ | mRNA |