X2C3Z8 · X2C3Z8_WHILA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Clitellata > Hirudinea > Hirudinida > Hirudiniformes > Haemopidae > Whitmania

Accessions

  • Primary accession
    X2C3Z8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-34Helical
Transmembrane54-80Helical
Transmembrane101-123Helical
Transmembrane143-168Helical
Transmembrane180-207Helical
Transmembrane227-255Helical
Transmembrane267-288Helical
Transmembrane300-322Helical
Transmembrane334-354Helical
Transmembrane374-393Helical
Transmembrane405-425Helical
Transmembrane445-469Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    511
  • Mass (Da)
    56,457
  • Last updated
    2014-06-11 v1
  • Checksum
    424AEE65C32C497E
MRWIYSTSHKDIGTLYFILGAWAAMLGSSMSSIIRIELSQPGSFLGDDQLYNSLVTAHGLVMIFFMVMPILIGGFGNWLLPLMVGAVDMSFPRLNNLSFWLLPPSMIMLLSSSMIEGGVGAGWTLYPPLSDSVSHSGPSVDMAIFSLHMAGASSILGSLNFISTIMNMRTKGMTTERVPLFVWSVVITTILLLLSLPVLAAAITMLLTDRNLNTTFFDPMGGGDPILFQHLFWFFGHPEVYILILPGFGAISHIVSGSSKKIEPFGSLGMIYAMIGIAVLGFIVWAHHMFTVGLDVDTRAYFTAATMVIAVPTGIKVFSWLATMYGSKVLYSPAMLWTIGFLFLFTMGGLTGLVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIFAAFNYWYPLFIGLGLNPILSLSQVYVMFLGVNITFFPQHFLGLSGMPRRMFSLSSCVYSLKCSIIIWFCINYCCFNFIYLLIDGSHSDHQRAMIFPGLAASLELLVQHTPLSYHSYNEIVPVYS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC688269
EMBL· GenBank· DDBJ
AGL34588.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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