W9BHQ6 · W9BHQ6_KLEPN

  • Protein
    ATP phosphoribosyltransferase
  • Gene
    hisG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Feedback inhibited by histidine.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP phosphoribosyltransferase
  • EC number
  • Short names
    ATP-PRT
    ; ATP-PRTase

Gene names

    • Name
      hisG
    • Synonyms
      hisG_1
    • ORF names
      APT92_22795
      , B5L96_09930
      , B6I68_18505
      , BANRA_01723
      , BANRA_03535
      , BL124_00001615
      , BV369_21850
      , CP554_26830
      , DM083_26800
      , DW281_27155
      , EAO17_04485
      , EXT45_24045
      , FME62_27075
      , FXN67_18820
      , G4V31_25690
      , GJJ01_27985
      , GJJ08_009040
      , GJJ18_01185
      , GNF00_04610
      , H3G96_018670
      , HV185_17740
      , I8R04_28575
      , JMZ77_08590
      , LS45_24255
      , NCTC11679_01845
      , NCTC13443_05084
      , NCTC5052_02320
      , NCTC9140_05580
      , NCTC9601_02255
      , NCTC9661_02652
      , Q6294_17340
      , SAMEA2273558_04399
      , SAMEA3499874_04600
      , SAMEA3499901_05024
      , SAMEA3515122_01653
      , SAMEA3538551_01912
      , SAMEA3538828_00144
      , SAMEA3649591_00674
      , SAMEA3649615_02198
      , SAMEA3720909_05221
      , SAMEA3729652_04790
      , SAMEA4364603_01148
      , SAMEA4873597_00121
      , SAMEA4873632_01969

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 53
    • 2429
    • 39383
    • 59493
    • 50627996
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    W9BHQ6
  • Secondary accessions
    • A0A0J2FZK4
    • A0A4V0GU82

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-219ATP phosphoribosyltransferase catalytic
Domain223-296Histidine biosynthesis HisG C-terminal

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    299
  • Mass (Da)
    33,214
  • Last updated
    2014-05-14 v1
  • Checksum
    6CE8BDCBB7EFE952
MLDNTRLRIAIQKSGRLSEDSRELLSRCGIKVNLHTQRLIALAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLSRRAQGEDPRYFTLRRLDFGGCRLSLATPVDEAWNGPAALDGKRIATSYPHLLKRYLDQKGISFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMADAKQQLIDRLLTRIQGVIQARESKYIMMHAPTERLEEVVALLPGAERPTILPLAGDKQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRRF01000023
EMBL· GenBank· DDBJ
KII01929.1
EMBL· GenBank· DDBJ
Genomic DNA
LNHP01000033
EMBL· GenBank· DDBJ
KSX89353.1
EMBL· GenBank· DDBJ
Genomic DNA
JAECTB010000043
EMBL· GenBank· DDBJ
MBH8353931.1
EMBL· GenBank· DDBJ
Genomic DNA
JAUUIA010000015
EMBL· GenBank· DDBJ
MDP0968795.1
EMBL· GenBank· DDBJ
Genomic DNA
WJVL01000040
EMBL· GenBank· DDBJ
MRJ99752.1
EMBL· GenBank· DDBJ
Genomic DNA
WJWF01000001
EMBL· GenBank· DDBJ
MRL34035.1
EMBL· GenBank· DDBJ
Genomic DNA
VINI01000038
EMBL· GenBank· DDBJ
MSS34407.1
EMBL· GenBank· DDBJ
Genomic DNA
WNPO01000008
EMBL· GenBank· DDBJ
MUA39129.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAKYD010000033
EMBL· GenBank· DDBJ
NGN75484.1
EMBL· GenBank· DDBJ
Genomic DNA
NDBK01000050
EMBL· GenBank· DDBJ
OVF73222.1
EMBL· GenBank· DDBJ
Genomic DNA
MSYX01000035
EMBL· GenBank· DDBJ
OWA78017.1
EMBL· GenBank· DDBJ
Genomic DNA
NCMJ01000103
EMBL· GenBank· DDBJ
PLE26222.1
EMBL· GenBank· DDBJ
Genomic DNA
PCFF01000068
EMBL· GenBank· DDBJ
PVU57901.1
EMBL· GenBank· DDBJ
Genomic DNA
CP055517
EMBL· GenBank· DDBJ
QLO20189.1
EMBL· GenBank· DDBJ
Genomic DNA
CP063008
EMBL· GenBank· DDBJ
QOU53535.1
EMBL· GenBank· DDBJ
Genomic DNA
CP066534
EMBL· GenBank· DDBJ
QQL32156.1
EMBL· GenBank· DDBJ
Genomic DNA
CP068602
EMBL· GenBank· DDBJ
QQZ73220.1
EMBL· GenBank· DDBJ
Genomic DNA
QOUB01000033
EMBL· GenBank· DDBJ
RCJ48769.1
EMBL· GenBank· DDBJ
Genomic DNA
QRCD01000048
EMBL· GenBank· DDBJ
RDT83983.1
EMBL· GenBank· DDBJ
Genomic DNA
MPYG04000014
EMBL· GenBank· DDBJ
ROH04827.1
EMBL· GenBank· DDBJ
Genomic DNA
RDAM01000001
EMBL· GenBank· DDBJ
RRF09687.1
EMBL· GenBank· DDBJ
Genomic DNA
SGOL01000026
EMBL· GenBank· DDBJ
RZG31733.1
EMBL· GenBank· DDBJ
Genomic DNA
FLDK01000012
EMBL· GenBank· DDBJ
SAT57812.1
EMBL· GenBank· DDBJ
Genomic DNA
UASN01000018
EMBL· GenBank· DDBJ
SPX55088.1
EMBL· GenBank· DDBJ
Genomic DNA
UFEU01000003
EMBL· GenBank· DDBJ
SSK25431.1
EMBL· GenBank· DDBJ
Genomic DNA
UGKQ01000007
EMBL· GenBank· DDBJ
STS83798.1
EMBL· GenBank· DDBJ
Genomic DNA
UGKT01000001
EMBL· GenBank· DDBJ
STT05133.1
EMBL· GenBank· DDBJ
Genomic DNA
UGLJ01000002
EMBL· GenBank· DDBJ
STT93902.1
EMBL· GenBank· DDBJ
Genomic DNA
UGLQ01000003
EMBL· GenBank· DDBJ
STU30049.1
EMBL· GenBank· DDBJ
Genomic DNA
UGMG01000001
EMBL· GenBank· DDBJ
STV49545.1
EMBL· GenBank· DDBJ
Genomic DNA
UIUC01000002
EMBL· GenBank· DDBJ
SVN62596.1
EMBL· GenBank· DDBJ
Genomic DNA
UJHH01000041
EMBL· GenBank· DDBJ
SWF77596.1
EMBL· GenBank· DDBJ
Genomic DNA
UJRG01000024
EMBL· GenBank· DDBJ
SWT22070.1
EMBL· GenBank· DDBJ
Genomic DNA
UKAW01000020
EMBL· GenBank· DDBJ
SXG18701.1
EMBL· GenBank· DDBJ
Genomic DNA
UKGE01000032
EMBL· GenBank· DDBJ
SXN33967.1
EMBL· GenBank· DDBJ
Genomic DNA
UKRD01000003
EMBL· GenBank· DDBJ
SYC18598.1
EMBL· GenBank· DDBJ
Genomic DNA
UKUT01000003
EMBL· GenBank· DDBJ
SYH30769.1
EMBL· GenBank· DDBJ
Genomic DNA
ULCI01000001
EMBL· GenBank· DDBJ
SYR26550.1
EMBL· GenBank· DDBJ
Genomic DNA
ULET01000004
EMBL· GenBank· DDBJ
SYU69822.1
EMBL· GenBank· DDBJ
Genomic DNA
VSSY01000017
EMBL· GenBank· DDBJ
TYL76702.1
EMBL· GenBank· DDBJ
Genomic DNA
UWVH01000001
EMBL· GenBank· DDBJ
VCV78460.1
EMBL· GenBank· DDBJ
Genomic DNA
UWWS01000001
EMBL· GenBank· DDBJ
VCX97099.1
EMBL· GenBank· DDBJ
Genomic DNA
CAAHAW010000001
EMBL· GenBank· DDBJ
VGJ09990.1
EMBL· GenBank· DDBJ
Genomic DNA
CAAHCC010000003
EMBL· GenBank· DDBJ
VGK81325.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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