W9BHQ6 · W9BHQ6_KLEPN
- ProteinATP phosphoribosyltransferase
- GenehisG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids299 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
Cofactor
Activity regulation
Feedback inhibited by histidine.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP phosphoribosyltransferase
- EC number
- Short namesATP-PRT ; ATP-PRTase
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionW9BHQ6
- Secondary accessions
Proteomes
Subcellular Location
Interaction
Subunit
Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 54-219 | ATP phosphoribosyltransferase catalytic | |||
Domain | 223-296 | Histidine biosynthesis HisG C-terminal | |||
Sequence similarities
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)33,214
- Last updated2014-05-14 v1
- Checksum6CE8BDCBB7EFE952
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JRRF01000023 EMBL· GenBank· DDBJ | KII01929.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LNHP01000033 EMBL· GenBank· DDBJ | KSX89353.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAECTB010000043 EMBL· GenBank· DDBJ | MBH8353931.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAUUIA010000015 EMBL· GenBank· DDBJ | MDP0968795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WJVL01000040 EMBL· GenBank· DDBJ | MRJ99752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WJWF01000001 EMBL· GenBank· DDBJ | MRL34035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VINI01000038 EMBL· GenBank· DDBJ | MSS34407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNPO01000008 EMBL· GenBank· DDBJ | MUA39129.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAKYD010000033 EMBL· GenBank· DDBJ | NGN75484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NDBK01000050 EMBL· GenBank· DDBJ | OVF73222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MSYX01000035 EMBL· GenBank· DDBJ | OWA78017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NCMJ01000103 EMBL· GenBank· DDBJ | PLE26222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PCFF01000068 EMBL· GenBank· DDBJ | PVU57901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP055517 EMBL· GenBank· DDBJ | QLO20189.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP063008 EMBL· GenBank· DDBJ | QOU53535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP066534 EMBL· GenBank· DDBJ | QQL32156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP068602 EMBL· GenBank· DDBJ | QQZ73220.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QOUB01000033 EMBL· GenBank· DDBJ | RCJ48769.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QRCD01000048 EMBL· GenBank· DDBJ | RDT83983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MPYG04000014 EMBL· GenBank· DDBJ | ROH04827.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RDAM01000001 EMBL· GenBank· DDBJ | RRF09687.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SGOL01000026 EMBL· GenBank· DDBJ | RZG31733.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FLDK01000012 EMBL· GenBank· DDBJ | SAT57812.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UASN01000018 EMBL· GenBank· DDBJ | SPX55088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFEU01000003 EMBL· GenBank· DDBJ | SSK25431.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGKQ01000007 EMBL· GenBank· DDBJ | STS83798.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGKT01000001 EMBL· GenBank· DDBJ | STT05133.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGLJ01000002 EMBL· GenBank· DDBJ | STT93902.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGLQ01000003 EMBL· GenBank· DDBJ | STU30049.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGMG01000001 EMBL· GenBank· DDBJ | STV49545.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UIUC01000002 EMBL· GenBank· DDBJ | SVN62596.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UJHH01000041 EMBL· GenBank· DDBJ | SWF77596.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UJRG01000024 EMBL· GenBank· DDBJ | SWT22070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKAW01000020 EMBL· GenBank· DDBJ | SXG18701.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKGE01000032 EMBL· GenBank· DDBJ | SXN33967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKRD01000003 EMBL· GenBank· DDBJ | SYC18598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKUT01000003 EMBL· GenBank· DDBJ | SYH30769.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ULCI01000001 EMBL· GenBank· DDBJ | SYR26550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ULET01000004 EMBL· GenBank· DDBJ | SYU69822.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VSSY01000017 EMBL· GenBank· DDBJ | TYL76702.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWVH01000001 EMBL· GenBank· DDBJ | VCV78460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWWS01000001 EMBL· GenBank· DDBJ | VCX97099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAAHAW010000001 EMBL· GenBank· DDBJ | VGJ09990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAAHCC010000003 EMBL· GenBank· DDBJ | VGK81325.1 EMBL· GenBank· DDBJ | Genomic DNA |