W8VNG9 · W8VNG9_9ADEN
- ProteinDNA-binding protein
- GeneE2A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids490 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 242 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 244 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 297 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 313 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 354 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 356 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 408 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 425 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Cellular Component | viral capsid | |
Molecular Function | DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | DNA-templated transcription | |
Biological Process | positive regulation of DNA replication | |
Biological Process | viral DNA strand displacement replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDNA-binding protein
- Short namesDBP
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus > Human mastadenovirus D
Accessions
- Primary accessionW8VNG9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Accumulates in infected cells.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 153 | Phosphotyrosine; by host | |||
Keywords
- PTM
Expression
Keywords
- Developmental stage
Interaction
Subunit
Homomultimerizes on viral ssDNA bound to pTP. Forms a initiation complex with viral polymerase, pTP and hosts NFIA and POU2F1/OCT1. Interacts with host SRCAP.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-85 | Disordered | |||
Compositional bias | 31-45 | Pro residues | |||
Domain | 143-219 | Adenovirus DNA-binding all-alpha | |||
Domain | 240-341 | Adenovirus DNA-binding zinc-binding | |||
Region | 255-289 | Flexible loop | |||
Domain | 353-448 | Adenovirus DNA-binding zinc-binding | |||
Region | 473-490 | C-terminal arm, DBP binding | |||
Domain
The C-terminal arm bridges DBP molecules together, thereby creating a chain.
Sequence similarities
Belongs to the adenoviridae E2A DNA-binding protein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length490
- Mass (Da)54,956
- Last updated2014-05-14 v1
- MD5 Checksum996A6A359B8FC2D358F7468DBD3BAA9F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 31-45 | Pro residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB765926 EMBL· GenBank· DDBJ | BAO53847.1 EMBL· GenBank· DDBJ | Genomic DNA |