W8VNG9 · W8VNG9_9ADEN

  • Protein
    DNA-binding protein
  • Gene
    E2A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP.

Features

Showing features for binding site.

149050100150200250300350400450
TypeIDPosition(s)Description
Binding site242Zn2+ 1 (UniProtKB | ChEBI)
Binding site244Zn2+ 1 (UniProtKB | ChEBI)
Binding site297Zn2+ 1 (UniProtKB | ChEBI)
Binding site313Zn2+ 1 (UniProtKB | ChEBI)
Binding site354Zn2+ 2 (UniProtKB | ChEBI)
Binding site356Zn2+ 2 (UniProtKB | ChEBI)
Binding site408Zn2+ 2 (UniProtKB | ChEBI)
Binding site425Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid
Molecular FunctionDNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA unwinding involved in DNA replication
Biological ProcessDNA-templated transcription
Biological Processpositive regulation of DNA replication
Biological Processviral DNA strand displacement replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA-binding protein
  • Short names
    DBP
  • Alternative names
    • Early 2A protein
    • Early E2A DNA-binding protein

Gene names

    • Name
      E2A
    • Synonyms
      DBP

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Chiba_E086/2012
  • Taxonomic lineage
    Viruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus > Human mastadenovirus D

Accessions

  • Primary accession
    W8VNG9

Proteomes

Subcellular Location

Host nucleus
Note: Accumulates in infected cells.

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue153Phosphotyrosine; by host

Keywords

Expression

Keywords

Interaction

Subunit

Homomultimerizes on viral ssDNA bound to pTP. Forms a initiation complex with viral polymerase, pTP and hosts NFIA and POU2F1/OCT1. Interacts with host SRCAP.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-85Disordered
Compositional bias31-45Pro residues
Domain143-219Adenovirus DNA-binding all-alpha
Domain240-341Adenovirus DNA-binding zinc-binding
Region255-289Flexible loop
Domain353-448Adenovirus DNA-binding zinc-binding
Region473-490C-terminal arm, DBP binding

Domain

The C-terminal arm bridges DBP molecules together, thereby creating a chain.

Sequence similarities

Belongs to the adenoviridae E2A DNA-binding protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    490
  • Mass (Da)
    54,956
  • Last updated
    2014-05-14 v1
  • MD5 Checksum
    996A6A359B8FC2D358F7468DBD3BAA9F
MAGGSQDVRRFMEREATPPRGHGSARYPPEQERSPSPPPPPLPTKRRKYQRVGSGSSEEDVVPVDSPLKKKQARKTKHVTKVDPDEEMPQEEAVIVGVGFSQPPVLLKEGKDGKRIVEPATPGVLNVRNPLSLPLVSSWEKGMDTMNVLMERYRVDSGLRDAYKLMPEQTEIFQKMCQTWMNEEARGLQLTFTTQKSFSTIMGRLLQGYIFSHSGIAHKNWECTGSALWDHGCTEVEGQLKCLHGTVMIHKDHVVEMDVTSENGQRALKEQPSKAKVTQNRWGRSVVQLTSHDARCCVQDAGCGNNQFSGKSCGLFFSEGAKAQQAFKQISAFVKALYPNMQRGAGMMLMPVHCECNHKPQSVPFLGRQLCKMTPFGLSNAEDLDKDQISDKSVLASVKHPSLMVFQCCNPVYRNSRAQSTGPNCDFKISAPDMLGALQMSRRMWSETFPEIPVPKLVIPEFKWQPKYQYRNVALPSAAHNDERENPFDF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias31-45Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB765926
EMBL· GenBank· DDBJ
BAO53847.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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