W8P5B9 · W8P5B9_9ALVE
- ProteinDerlin
- GeneDer1-Pla
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids332 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Hrd1p ubiquitin ligase ERAD-L complex | |
Molecular Function | misfolded protein binding | |
Molecular Function | ubiquitin-specific protease binding | |
Biological Process | endoplasmic reticulum unfolded protein response |
Names & Taxonomy
Protein names
- Recommended nameDerlin
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Colpodellida > Chromeraceae > Chromera
Accessions
- Primary accessionW8P5B9
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 129-145 | Helical | ||||
Sequence: GYLLLSTALCLAVYSMN | ||||||
Transmembrane | 166-188 | Helical | ||||
Sequence: LWRVVTPFFYLGSMGFSYYLNVA | ||||||
Transmembrane | 208-228 | Helical | ||||
Sequence: FAVMVLFAAVFLLGASPAMGV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MKETAGVRRRALVVCVWLCCVVACSCS | ||||||
Chain | PRO_5004911136 | 28-332 | Derlin | |||
Sequence: SSGLSPSTLSGRGRRRQEGVLPSECCSSSSPSLQSASLPAVLRLRGGAGDGEEGDAWGDEGVDGFDDEHDDEDEETFTDYGGQSPAEKALDALKKMPPITKGYLLLSTALCLAVYSMNDNVWPQSLKLNWQRVFRWGELWRVVTPFFYLGSMGFSYYLNVAFVNQYMGSLEKIQYKSPEEFAVMVLFAAVFLLGASPAMGVPNEMLGHNLATFMLYVWSRTYEGLEVNLFNYMSVRAEYLPWLFLAQSWLLEGQNPAFELMGIAAGWVYHWLKGRRILRAPRFLRRLFEKEAVQREYARFAEEFE |
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 76-108 | Disordered | ||||
Sequence: GDGEEGDAWGDEGVDGFDDEHDDEDEETFTDYG | ||||||
Compositional bias | 80-105 | Acidic residues | ||||
Sequence: EGDAWGDEGVDGFDDEHDDEDEETFT |
Sequence similarities
Belongs to the derlin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length332
- Mass (Da)37,450
- Last updated2014-05-14 v1
- Checksum6843686C2DB73A8F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 80-105 | Acidic residues | ||||
Sequence: EGDAWGDEGVDGFDDEHDDEDEETFT |