W8P5B9 · W8P5B9_9ALVE

  • Protein
    Derlin
  • Gene
    Der1-Pla
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentHrd1p ubiquitin ligase ERAD-L complex
Molecular Functionmisfolded protein binding
Molecular Functionubiquitin-specific protease binding
Biological Processendoplasmic reticulum unfolded protein response

Names & Taxonomy

Protein names

  • Recommended name
    Derlin

Gene names

    • Name
      Der1-Pla

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CCAP 1602/1
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Colpodellida > Chromeraceae > Chromera

Accessions

  • Primary accession
    W8P5B9

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane129-145Helical
Transmembrane166-188Helical
Transmembrane208-228Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_500491113628-332Derlin

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region76-108Disordered
Compositional bias80-105Acidic residues

Sequence similarities

Belongs to the derlin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    332
  • Mass (Da)
    37,450
  • Last updated
    2014-05-14 v1
  • Checksum
    6843686C2DB73A8F
MKETAGVRRRALVVCVWLCCVVACSCSSSGLSPSTLSGRGRRRQEGVLPSECCSSSSPSLQSASLPAVLRLRGGAGDGEEGDAWGDEGVDGFDDEHDDEDEETFTDYGGQSPAEKALDALKKMPPITKGYLLLSTALCLAVYSMNDNVWPQSLKLNWQRVFRWGELWRVVTPFFYLGSMGFSYYLNVAFVNQYMGSLEKIQYKSPEEFAVMVLFAAVFLLGASPAMGVPNEMLGHNLATFMLYVWSRTYEGLEVNLFNYMSVRAEYLPWLFLAQSWLLEGQNPAFELMGIAAGWVYHWLKGRRILRAPRFLRRLFEKEAVQREYARFAEEFE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias80-105Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ194480
EMBL· GenBank· DDBJ
AHL28474.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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