W8GSI8 · W8GSI8_PRUMU

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloroplast
Cellular ComponentDNA-directed RNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionprotein dimerization activity
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit alpha
  • EC number
  • Short names
    RNAP subunit alpha
  • Alternative names
    • RNA polymerase subunit alpha
    • Transcriptase subunit alpha

Gene names

    • Name
      rpoA

Encoded on

  • Plastid

Organism names

  • Taxonomic identifier
  • Strain
    • BJFU1210120008
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Rosaceae > Amygdaloideae > Amygdaleae > Prunus

Accessions

  • Primary accession
    W8GSI8

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-234Alpha N-terminal domain (alpha-NTD)
Domain29-232DNA-directed RNA polymerase RpoA/D/Rpb3-type
Region269-326Alpha C-terminal domain (alpha-CTD)

Domain

The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

Sequence similarities

Belongs to the RNA polymerase alpha chain family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    326
  • Mass (Da)
    37,579
  • Last updated
    2014-05-14 v1
  • Checksum
    ABDB2D860CEC41E3
MVREKVTVSTRTLQWKCVESRADSKRLYYGRFILAPLMKGQADTIGIAMRRALLGEIEGTCITRAKSEKIPHEYSTIIGIQESVHEILMNLKEIVLRSNLYGTRNASICIKGPGYVTAQDIILPPSVEIVDNTQHIANLTEPINLCIELQIERNRGYRIKTPNNFQDGSYPIDAVFMPVRNANHSIHSYVNGNEKQEILFLEIWTNGSLTPKEALHDASRNLIDLFIPFLHAEEENLQLENNQHKVTLPLFTFHGRLAKQRKNKKEIALQYIFIDQSELFPRVYNCLKRSNIHTLLDLLNNSQEDLMKIKHFRIEDVKHILNILEI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF765450
EMBL· GenBank· DDBJ
AHK26905.1
EMBL· GenBank· DDBJ
Genomic DNA
MH700953
EMBL· GenBank· DDBJ
QJA14099.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp