Long non-coding RNA CDKN2B-AS1 enhances LPS-induced apoptotic and inflammatory damages in human lung epithelial cells via regulating the miR-140-5p/TGFBR2/Smad3 signal network.
The increase in protein expression level of the ligand TGFbeta1 was 285 +/- 1.15% higher and its receptor TGFbetaRII was 170 +/- 0.98% higher in hippocampus of patients with Hippocampal Sclerosis (HS) in comparison to the autopsy hippocampal control samples. The expression of the downstream signalling molecules SMAD3 is 157 +/- 0.13% and 106 +/- 0.17% higher in patients with HS as compared to both types of non-seizure...
the restoration of TGFBR2 in miR-204 overexpression Gastric cancer (GC) cells which recovered resistance to 5-FU treatments compared with miR-204 overexpression GC cells.
Results show that TGFbR2 expression decreases in human gastric cancer (GC) tissue specimens and indicate that the expression of TGFbR2 is mainly dependent on post-transcriptional regulators in GC through miR-155 binding to the 3'-UTR of its mRNA.
Microarray-based analyses revealed that the expression of miR-20b was significantly increased whereas TGFBR2 and MYC were significantly downregulated and upregulated respectively in all ES cells compared to their expression in human mesenchymal stem cells (hMSCs).
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