W8DV10 · W8DV10_DROSN

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 2
  • EC number

Gene names

    • Name
      ND2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • San_BS11
    • San_BS13
    • San_Car
    • San_Cost
    • San_field4
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    W8DV10

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-34Helical
Transmembrane60-80Helical
Transmembrane92-114Helical
Transmembrane120-141Helical
Transmembrane148-168Helical
Transmembrane197-218Helical
Transmembrane238-261Helical
Transmembrane273-299Helical
Transmembrane319-339Helical

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-285NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain286-337NADH dehydrogenase subunit 2 C-terminal

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    39,496
  • Last updated
    2014-05-14 v1
  • Checksum
    E6117DE50BE9D4AF
MFYNSSKILFTTIMIIGTLITVTSNSWLGAWMGLEINLLSFIPLLSDNNNLMSTEASLKYFLTQALASTVLLFSSILLMLANNLNNEINESFTSMIIMSALLLKSGAAPFHFWFPNMMEGLTWMNALMLMTWQKIAPLMLISYLNIKNLLLISVILSVIIGAIGGLNQTSLRKLMAFSSINHLGWMLSSLMISESIWLIYFIFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFSLFMNFLSLGGLPPFLGFLPKWLVIQQLTMCNQYFLLTLMMMSTLITLFFYLRICYSAFMLNYFENNWIMEMNMNSNNTNLYLIMTFFSIFGLFLISLFFFML

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF824856
EMBL· GenBank· DDBJ
AHG53180.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824857
EMBL· GenBank· DDBJ
AHG53193.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824859
EMBL· GenBank· DDBJ
AHG53219.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824860
EMBL· GenBank· DDBJ
AHG53232.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824861
EMBL· GenBank· DDBJ
AHG53245.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824862
EMBL· GenBank· DDBJ
AHG53258.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824863
EMBL· GenBank· DDBJ
AHG53271.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824864
EMBL· GenBank· DDBJ
AHG53284.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824865
EMBL· GenBank· DDBJ
AHG53297.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824866
EMBL· GenBank· DDBJ
AHG53310.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824867
EMBL· GenBank· DDBJ
AHG53323.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824868
EMBL· GenBank· DDBJ
AHG53336.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824869
EMBL· GenBank· DDBJ
AHG53349.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824870
EMBL· GenBank· DDBJ
AHG53362.1
EMBL· GenBank· DDBJ
Genomic DNA
KF824872
EMBL· GenBank· DDBJ
AHG53388.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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