W8CJN3 · W8CJN3_HRSV
- ProteinMajor surface glycoprotein G
- GeneG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids298 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities.
Isoform Secreted glycoprotein G
Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host cell plasma membrane | |
Cellular Component | plasma membrane | |
Cellular Component | virion membrane | |
Biological Process | symbiont entry into host cell | |
Biological Process | virion attachment to host cell | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMajor surface glycoprotein G
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Pneumoviridae > Orthopneumovirus > Orthopneumovirus hominis
- Virus hosts
Accessions
- Primary accessionW8CJN3
Subcellular Location
UniProt Annotation
GO Annotation
Host cell membrane ; Single-pass type II membrane protein
Virion membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 41-63 | Helical | ||||
Sequence: ITLSILAMIISTSLIIAAIIFIA |
Keywords
- Cellular component
Interaction
Subunit
Homooligomer. Interacts (via N-terminus) with protein M. Part of a complex composed of F1, F2 and G glycoproteins. Interacts with protein SH. Interacts with host heparate sulfate; this interaction probably participates in the viral attachment to the host cell. Interacts with host CX3CR1; this interaction plays an important role in viral entry. Interacts with the host lectins CD209/DC-SIGN and CD209L/L-SIGN on dendritic cells; these interactions stimulate the phosphorylation of MAPK3/ERK1 and MAPK1/ERK2, which inhibits dendritic cell activation and could participate in the limited immunity against RSV reinfection.
Isoform Membrane-bound glycoprotein G
Homooligomer. Interacts (via N-terminus) with protein M. Part of a complex composed of F1, F2 and G glycoproteins. Interacts with protein SH. Interacts with host heparate sulfate; this interaction probably participates in the viral attachment to the host cell.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 125-161 | Disordered | ||||
Sequence: TPQSTTVKIKNTTTTQMQPSKPTTKQRQNKPQNKPNN | ||||||
Region | 190-298 | Disordered | ||||
Sequence: PNKKPGKKTTTKPTKKPTIKTTKKDPKPQTTKPKEVLTTKPTEKPTINTTKTNIKTTLLTSNTTENPEHTSQKETLHSTTSEGNPSPSQVYTTSEYLSQSLSPSNTTKW | ||||||
Compositional bias | 221-298 | Polar residues | ||||
Sequence: KPKEVLTTKPTEKPTINTTKTNIKTTLLTSNTTENPEHTSQKETLHSTTSEGNPSPSQVYTTSEYLSQSLSPSNTTKW |
Sequence similarities
Belongs to the pneumoviruses glycoprotein G family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length298
- Mass (Da)33,071
- Last updated2014-05-14 v1
- Checksum43F221102774AE2C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 221-298 | Polar residues | ||||
Sequence: KPKEVLTTKPTEKPTINTTKTNIKTTLLTSNTTENPEHTSQKETLHSTTSEGNPSPSQVYTTSEYLSQSLSPSNTTKW |