W8C2W4 · W8C2W4_CERCA

Function

Catalytic activity

  • heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
    EC:7.6.2.5 (UniProtKB | ENZYME | Rhea)
  • pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentearly endosome membrane
Cellular Componentextracellular region
Cellular ComponentGolgi membrane
Cellular Componentlysosomal membrane
Cellular Componentmelanosome membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentmultivesicular body membrane
Molecular FunctionABC-type heme transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionheme binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-binding cassette sub-family B member 6
  • EC number
  • Alternative names
    • ABC-type heme transporter ABCB6

Gene names

    • Name
      ABCB6
    • ORF names
      CCAP1982_LOCUS4817

Organism names

Accessions

  • Primary accession
    W8C2W4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Early endosome membrane
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endosome membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein
Late endosome membrane
Lysosome membrane
Melanosome membrane
Mitochondrion outer membrane
; Multi-pass membrane protein
Secreted, extracellular exosome

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-45Helical
Transmembrane65-85Helical
Transmembrane97-118Helical
Transmembrane134-153Helical
Transmembrane173-191Helical
Transmembrane240-266Helical
Transmembrane363-386Helical
Transmembrane392-412Helical
Transmembrane483-501Helical
Transmembrane513-532Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain247-537ABC transmembrane type-1
Domain571-805ABC transporter
Compositional bias812-828Basic and acidic residues
Region812-838Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    858
  • Mass (Da)
    97,445
  • Last updated
    2014-04-16 v1
  • Checksum
    C2999CD0AC6DD34A
MLYCPPNVTFSQVWINNGISHCFMDTIGNTVASGFMLLMGTVQLLMYRKYATRNDPTHITKSRLYALQLFLLFFFPILALIRFFLNARIYNDHAVYGYMILSTVLICISYPFSVCVIIKERFYQLPSLPTRGHGLILLLFWTLGFINESLAFINLRHEDWWFTLKTNKDQIEMGLFVTRFITSLLIFILGLKAPGIMRPYVQLDEPTNGNTSNIQQGSAFRNAFKKLAKLFPYMWPKKDVLLQLSVITCILLLISGRVIKLFLPIYRKKLVDSLTIAPIIFRWDFVLIYVALSFVQGGGTGTMGLFNNLRSFLWIRVQQYTTREIEVDLFNHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYIIFSITPTIIDLLVAVVFFIYAFNWWFGLIVFLTMFLYILATILVTEWRTKYQRRMNLADNAQRARSVDSLLNFETVKYYGAEQYEVDEYRKAIINYQKEEFLSMLTLNLLNTSQNIILCLGLLCGSMLCVYLVAHHQTLTVGDFVLFFTYLMDLYMPLNWFGTYYRAIQKNFVDMENMFDLLKEDQEIFDAPGAAPLITAGAGIEFSNVTFGYTPEKIVLRNVSFSVPPGKTVAIVGPSGAGKSTIVRLLFRFYDVQSGAVLIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYGKIGARADEVYEAARLADIHDRILGFPDRYETKVGERGLRLSGGEKQRVAIARTLLKAPVLVLLDEATSALDTNTERNIQAALARVCSNRTTIVIAHRLSTIINADEILVIKDGTIAERGRHDDLLQRKDGIYAEMWMQQLKNLEGNKESDESDDAKAANGTERASDAVGGSGSVVAGAVLRAGHAHGGAR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias812-828Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJHJT010000001
EMBL· GenBank· DDBJ
CAD6996122.1
EMBL· GenBank· DDBJ
Genomic DNA
GAMC01002992
EMBL· GenBank· DDBJ
JAC03564.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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