W8C2W4 · W8C2W4_CERCA
- ProteinATP-binding cassette sub-family B member 6
- GeneABCB6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids858 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.heme b (in)CHEBI:60344
+ CHEBI:30616 + CHEBI:15377 = heme b (out)CHEBI:60344+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378 - pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | extracellular region | |
Cellular Component | Golgi membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | melanosome membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | multivesicular body membrane | |
Molecular Function | ABC-type heme transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | heme binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-binding cassette sub-family B member 6
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Tephritoidea > Tephritidae > Ceratitis > Ceratitis
Accessions
- Primary accessionW8C2W4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endosome membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 26-45 | Helical | ||||
Sequence: TIGNTVASGFMLLMGTVQLL | ||||||
Transmembrane | 65-85 | Helical | ||||
Sequence: YALQLFLLFFFPILALIRFFL | ||||||
Transmembrane | 97-118 | Helical | ||||
Sequence: GYMILSTVLICISYPFSVCVII | ||||||
Transmembrane | 134-153 | Helical | ||||
Sequence: GLILLLFWTLGFINESLAFI | ||||||
Transmembrane | 173-191 | Helical | ||||
Sequence: MGLFVTRFITSLLIFILGL | ||||||
Transmembrane | 240-266 | Helical | ||||
Sequence: VLLQLSVITCILLLISGRVIKLFLPIY | ||||||
Transmembrane | 363-386 | Helical | ||||
Sequence: LLNYIIFSITPTIIDLLVAVVFFI | ||||||
Transmembrane | 392-412 | Helical | ||||
Sequence: WFGLIVFLTMFLYILATILVT | ||||||
Transmembrane | 483-501 | Helical | ||||
Sequence: IILCLGLLCGSMLCVYLVA | ||||||
Transmembrane | 513-532 | Helical | ||||
Sequence: LFFTYLMDLYMPLNWFGTYY |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 247-537 | ABC transmembrane type-1 | ||||
Sequence: ITCILLLISGRVIKLFLPIYRKKLVDSLTIAPIIFRWDFVLIYVALSFVQGGGTGTMGLFNNLRSFLWIRVQQYTTREIEVDLFNHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYIIFSITPTIIDLLVAVVFFIYAFNWWFGLIVFLTMFLYILATILVTEWRTKYQRRMNLADNAQRARSVDSLLNFETVKYYGAEQYEVDEYRKAIINYQKEEFLSMLTLNLLNTSQNIILCLGLLCGSMLCVYLVAHHQTLTVGDFVLFFTYLMDLYMPLNWFGTYYRAIQK | ||||||
Domain | 571-805 | ABC transporter | ||||
Sequence: IEFSNVTFGYTPEKIVLRNVSFSVPPGKTVAIVGPSGAGKSTIVRLLFRFYDVQSGAVLIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYGKIGARADEVYEAARLADIHDRILGFPDRYETKVGERGLRLSGGEKQRVAIARTLLKAPVLVLLDEATSALDTNTERNIQAALARVCSNRTTIVIAHRLSTIINADEILVIKDGTIAERGRHDDLLQRKDGIYAEMWM | ||||||
Compositional bias | 812-828 | Basic and acidic residues | ||||
Sequence: EGNKESDESDDAKAANG | ||||||
Region | 812-838 | Disordered | ||||
Sequence: EGNKESDESDDAKAANGTERASDAVGG |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length858
- Mass (Da)97,445
- Last updated2014-04-16 v1
- ChecksumC2999CD0AC6DD34A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 812-828 | Basic and acidic residues | ||||
Sequence: EGNKESDESDDAKAANG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAJHJT010000001 EMBL· GenBank· DDBJ | CAD6996122.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GAMC01002992 EMBL· GenBank· DDBJ | JAC03564.1 EMBL· GenBank· DDBJ | mRNA |