W7WM28 · W7WM28_9BURK

  • Protein
    NADH-quinone oxidoreductase subunit B
  • Gene
    nuoB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site38[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site102[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site132[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane respiratory chain complex I
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioniron ion binding
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding
Biological Processaerobic respiration
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit B
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit B
    • NDH-1 subunit B

Gene names

    • Name
      nuoB
    • ORF names
      Y694_01166

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • T29-B
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Sphaerotilaceae > Methylibium

Accessions

  • Primary accession
    W7WM28

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-146NADH:ubiquinone oxidoreductase-like 20kDa subunit

Sequence similarities

Belongs to the complex I 20 kDa subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    158
  • Mass (Da)
    17,476
  • Last updated
    2014-04-16 v1
  • Checksum
    F3EC8B06AE780694
MGIEGVLKEGFITTSADKLINWSKTGSLWPMTFGLACCAVEMMHAGAARYDIDRFGMLFRPSPRQSDLMIVAGTLCNKMAPALRRVYDQMAEPRWVLSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALLYGILQLQAKIRRENTIAR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZSN01000020
EMBL· GenBank· DDBJ
EWS61064.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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