W7W703 · W7W703_9BURK

  • Protein
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • Gene
    dut
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site68-70substrate
Binding site81substrate
Binding site85-87substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • ORF names
      Y694_03796

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • T29-B
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Sphaerotilaceae > Methylibium

Accessions

  • Primary accession
    W7W703

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-147dUTPase-like

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    149
  • Mass (Da)
    15,592
  • Last updated
    2014-04-16 v1
  • Checksum
    8D4EFA4220C79606
MTTIDVKVLDPRMADQLPAYATPGSAGLDLRACLDAPLLLEPGQTQLIPTGLSIHIGDPGLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRGPAAFTVQPLERIAQLVIVPVVQASFRVVDDFGASERGEGGFGSTGQR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZSN01000146
EMBL· GenBank· DDBJ
EWS58321.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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