W7W703 · W7W703_9BURK
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- Genedut
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids149 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = diphosphate + dUMP + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 68-70 | substrate | ||||
Sequence: RSG | ||||||
Binding site | 81 | substrate | ||||
Sequence: N | ||||||
Binding site | 85-87 | substrate | ||||
Sequence: LID |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Sphaerotilaceae > Methylibium
Accessions
- Primary accessionW7W703
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-147 | dUTPase-like | ||||
Sequence: LPAYATPGSAGLDLRACLDAPLLLEPGQTQLIPTGLSIHIGDPGLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRGPAAFTVQPLERIAQLVIVPVVQASFRVVDDFGASERGEGGFGSTG |
Sequence similarities
Belongs to the dUTPase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length149
- Mass (Da)15,592
- Last updated2014-04-16 v1
- Checksum8D4EFA4220C79606
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AZSN01000146 EMBL· GenBank· DDBJ | EWS58321.1 EMBL· GenBank· DDBJ | Genomic DNA |