W7W694 · W7W694_9BURK
- ProteinFormylmethanofuran--tetrahydromethanopterin formyltransferase
- GenefhcD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids307 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H4MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H4MPT).
Catalytic activity
- 5,6,7,8-tetrahydromethanopterin + H+ + N-formylmethanofuran = methanofuran + N5-formyl-5,6,7,8-tetrahydromethanopterin
Pathway
One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H4MPT route): step 4/5.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity | |
Molecular Function | hydrolase activity | |
Biological Process | formaldehyde catabolic process | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFormylmethanofuran--tetrahydromethanopterin formyltransferase
- EC number
- Short namesFtr
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Sphaerotilaceae > Methylibium
Accessions
- Primary accessionW7W694
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-143 | Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal | ||||
Sequence: MELNGIVIDDSFAEAFPMKGTRLVITAHNLEWARHAAVATTGFATSVIACGCEAGIERELAPEETPDGRPGIAILIFSMSGRELAKQVEKRVGQCVLTCPTTAVYAGLFEGDAIALGKNLRFFGDGWQTSKVIGGQRYWRVPV | ||||||
Domain | 146-298 | Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal | ||||
Sequence: GEFVAQETTWVTTQAVGGGNLLLLATDTAAALAAAEAAVAAMKQLPNIVMPFPGGVVRSGSKVGSKYPTLGASTNDAYCPSLRELAAKSELGPDIGSVMEIVIDGLTDADVAAAMRTGLKTLIERGAASGLKRIGAGNYGGKLGPFLYHLHKL |
Sequence similarities
Belongs to the FTR family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length307
- Mass (Da)32,082
- Last updated2014-04-16 v1
- Checksum642371830C5502AC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AZSN01000171 EMBL· GenBank· DDBJ | EWS58081.1 EMBL· GenBank· DDBJ | Genomic DNA |