W7N466 · FDB3_GIBM7
- ProteinTranscription factor FBD3
- GeneFDB3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids748 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Transcription factor; part of the Fusarium detoxification of benzoxazolinone cluster 2 (FDB2) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:19302487, PubMed:26808652).
Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).
FDB3 is not essentiel, but contributes to efficient BOA biotransformation (PubMed:19302487).
Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).
FDB3 is not essentiel, but contributes to efficient BOA biotransformation (PubMed:19302487).
Miscellaneous
Fusarium verticillioides possesses 2 unlinked loci, FDB1 and FDB2, necessary for detoxification of antimicrobial compounds produced by maize, including 2-benzoxazolinone (BOA) (Probable). The FDB2 cluster arose as a duplication of the FDB1 cluster with rearrangement and expansion by incorporating additional genes (Probable).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 32-59 | Zn2-C6 fungal-type | ||||
Sequence: CNACRSRKSRCDGQRPSCSSCLSLGFDC |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | DNA-templated transcription | |
Biological Process | positive regulation of transcription from RNA polymerase II promoter by galactose |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscription factor FBD3
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium fujikuroi species complex
Accessions
- Primary accessionW7N466
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Decreases, but does not eliminate the ability to metabolize 2-benzoxasolinone (BOA).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000454603 | 1-748 | Transcription factor FBD3 | |||
Sequence: MPEQPRRPSDQEQNQSETGPPTNKRRRIGLACNACRSRKSRCDGQRPSCSSCLSLGFDCMYEPGDSATNVIVRKDYVTDLEQRVSSVEHNLQRLNDVLKGHLSPCTNANTSPCHHGTINAGPSMPSPAPTAPTKASAPSGARTGTCATSLEEPQDEEGIPNGMAMTFVEEKTSAFYGEASNINFTQLLLRAIAVAHDSPGAPSGLDRASVLGESVVASVSQSKSSLGGTATPFDSLPTALPSVEEMDTLLDLYFDTAGVVFPFIHEETMRKTYNECRLNGFTRARRTWLGTLNMVFAMASNFDRDYTTSSKKRFERSNIFYKRAMGLCNELSKRVISLEIVHYLILVVLHCQGTSRSVQAWNNYGLVIRSAMALGLHAESTERALNPVQKEYRRRTWVVIYCLDKVLSTAVGRPASIPDEQMMRREPSSGRSPATSGNAADLPGDFLAVSFRMYQVMSKSLVIQYGANLDHDSELDEMAHLKASGELRKQLRLWAANLPPHLQLCDVESDVLLQNTKANRLRVILTMRYHNLSILIHKPLLSATILHLFRQGDAANDASSYLIQLAMAEAHECIRSAQLTIDIVHSVITVDATSKNNLGVWYFTLYYVFTASLVICGRLLWAQHGDTVVDEASASHMRFLLGKAETIFLNLDHENSLVLSCLEYVRRLSRMCGIRETGPDAASASIHDNGSNSTGSADAMSFDLDNMDPFQLFASEMFDPAIFDHFNQSPVDGMSFVNGLWDGFPCGG |
Expression
Induction
Expression is induced in response to 2-benzoxasolinone (BOA) exposure.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-26 | Disordered | ||||
Sequence: MPEQPRRPSDQEQNQSETGPPTNKRR | ||||||
Compositional bias | 7-22 | Polar residues | ||||
Sequence: RPSDQEQNQSETGPPT | ||||||
Region | 116-160 | Disordered | ||||
Sequence: GTINAGPSMPSPAPTAPTKASAPSGARTGTCATSLEEPQDEEGIP | ||||||
Compositional bias | 136-150 | Polar residues | ||||
Sequence: SAPSGARTGTCATSL | ||||||
Region | 417-438 | Disordered | ||||
Sequence: IPDEQMMRREPSSGRSPATSGN |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length748
- Mass (Da)82,410
- Last updated2014-04-16 v1
- Checksum373249F9CCD7F632
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 7-22 | Polar residues | ||||
Sequence: RPSDQEQNQSETGPPT | ||||||
Compositional bias | 136-150 | Polar residues | ||||
Sequence: SAPSGARTGTCATSL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU567121 EMBL· GenBank· DDBJ | ACE00535.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CM000580 EMBL· GenBank· DDBJ | EWG54414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000580 EMBL· GenBank· DDBJ | EWG54415.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CM000580 EMBL· GenBank· DDBJ | EWG54416.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |