W7MQL0 · W7MQL0_GIBM7
- ProteinATP-dependent DNA helicase CHL1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids864 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA damage response | |
Biological Process | establishment of sister chromatid cohesion | |
Biological Process | nucleobase-containing compound metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase CHL1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium fujikuroi species complex
Accessions
- Primary accessionW7MQL0
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-442 | Helicase ATP-binding | ||||
Sequence: EKLNFHHPYTPYAVQEQFMKAVYNVLETGNGQVGILESPTGTGKSLSLICASLTWLRNHKSNQLEASIQESAEAYKDEPSWLVEQLLRRKREELVTRWEDREKRLETLRLKEKAQEERSRKRRRVEDFVPSRSRVEDEDAEWLLDDPDDLDTGPHDALSGLSKETREVLASIGLGGAKKPEQEDDLLEEPIKIYYTSRTHSQLSQFITELRRPSFPPSLPISLAKSEETKIEAVKLLPLSSRQRLCINPTVSRLGSVQAINDRCSELQQPKSGQKCPFVPKEDLISQTHQFRDSALATLPDIEDLHQLGKSLSVCPYYASRTALPGAEIITLPYPLLLQKSARDALGVKLEGSVVIIDEAHNIMDAVANVHAAEIKLSDLRRGRAMLGVYVKKFGKKLKGVNRVNVGRVGRVIDGLSEWMDGALKFKQE |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length864
- Mass (Da)96,105
- Last updated2014-04-16 v1
- Checksum07A98A7A6220E4CE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS022250 EMBL· GenBank· DDBJ | EWG46907.1 EMBL· GenBank· DDBJ | Genomic DNA |