W7KGE5 · AQP2_PLAFO
- ProteinAquaporin-2
- GeneAQP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids603 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Required for sporozoite development in the mosquito vector.
Catalytic activity
- H2O(in) = H2O(out)
- glycerol(in) = glycerol(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endomembrane system | |
Cellular Component | plasma membrane | |
Molecular Function | water channel activity | |
Biological Process | development of symbiont in host |
Names & Taxonomy
Protein names
- Recommended nameAquaporin-2
- Short namesPfAQP2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionW7KGE5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endomembrane system ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 40-70 | Helical | ||||
Sequence: SLKKYKYNLFFEFIGSFLFVFFISIYMLNSN | ||||||
Transmembrane | 282-299 | Helical | ||||
Sequence: HAIYSFVGCFIYVIFILL | ||||||
Transmembrane | 321-346 | Helical | ||||
Sequence: FALSTLYITFQYFGGIVASIICAHLY | ||||||
Transmembrane | 360-393 | Helical | ||||
Sequence: IIKTFLCEFISTFLITLLLLSLYNYKKKFMEENK | ||||||
Transmembrane | 442-471 | Helical | ||||
Sequence: NKYIKYIMNHIFYLLFIFFSLLFFVFVTNT | ||||||
Transmembrane | 509-542 | Helical | ||||
Sequence: ITKIFQLLIFYIQSLPLWIGPYFGSAFAATFLSL |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Dramatic reduction in development of mature sporozoites in the mosquito vector with no impact on any of the preceding stages.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000460638 | 1-603 | Aquaporin-2 | |||
Sequence: MKIQKGLFFLQRSIKNVLRKIIKFIKGYVKDIIKEINVKSLKKYKYNLFFEFIGSFLFVFFISIYMLNSNSNEEYIIKHTKQINPYKTNDILIPGHNNFEAEINNIKYMNNLNQERKNVVASILLEKYDNEYKGNNKSKREVERDDDKISNNLQNEFEKDNEKKKNYDNINEKEISTTSDGKIKDMEDPKNISNKNENYDNTNMELKNEKINNKVNDEKNIKNEDDINNKENMLKSVDKIIFKEPVNEYSKIKIEDINNINLKDIDQYEVLKNSENKKSSNHAIYSFVGCFIYVIFILLGAHINPAYTYALWLTEPKKYGFALSTLYITFQYFGGIVASIICAHLYGSIFIYTLLPKKEIIKTFLCEFISTFLITLLLLSLYNYKKKFMEENKNDESLTFNINKLRNMSSLYNFNTYEDFYSYDMFSTNQNRKYNSFLYIDNKYIKYIMNHIFYLLFIFFSLLFFVFVTNTTLNPMFSTSTLYTYLYYKIFKASNSFKIYSIFISFLSITKIFQLLIFYIQSLPLWIGPYFGSAFAATFLSLFKENEEEIINIIDTNVYSSYNKKKEQIPLIDKNSAKQNAYLIEYNDNIHNNSYNYLLPSVF |
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 135-194 | Basic and acidic residues | ||||
Sequence: NNKSKREVERDDDKISNNLQNEFEKDNEKKKNYDNINEKEISTTSDGKIKDMEDPKNISN | ||||||
Region | 135-200 | Disordered | ||||
Sequence: NNKSKREVERDDDKISNNLQNEFEKDNEKKKNYDNINEKEISTTSDGKIKDMEDPKNISNKNENYD |
Domain
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop (By similarity).
One of the two canonical Asn-Pro-Ala (NPA) motifs in the pore region, which are highly conserved in aquaporin water channels, is changed to Asn-Pro-Met (NPM) (PubMed:37883438).
One of the two canonical Asn-Pro-Ala (NPA) motifs in the pore region, which are highly conserved in aquaporin water channels, is changed to Asn-Pro-Met (NPM) (PubMed:37883438).
Sequence similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length603
- Mass (Da)71,625
- Last updated2014-04-16 v1
- ChecksumBD97A32E7BE231E2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 135-194 | Basic and acidic residues | ||||
Sequence: NNKSKREVERDDDKISNNLQNEFEKDNEKKKNYDNINEKEISTTSDGKIKDMEDPKNISN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KE123791 EMBL· GenBank· DDBJ | EWC88897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QFXU01000009 EMBL· GenBank· DDBJ | KAF4330236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NYMT01000006 EMBL· GenBank· DDBJ | PKC47379.1 EMBL· GenBank· DDBJ | Genomic DNA |