W7IAA8 · W7IAA8_9PEZI

Function

function

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular ComponentGolgi apparatus
Cellular Componentmembrane
Biological ProcessGolgi to endosome transport
Biological ProcessGolgi to vacuole transport
Biological Processprotein targeting to vacuole

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Vacuolar protein sorting/targeting protein 10
  • Alternative names
    • Carboxypeptidase Y receptor
    • Sortilin VPS10

Gene names

    • ORF names
      DRE_04768

Organism names

  • Taxonomic identifier
  • Strain
    • 248
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Orbiliomycetes > Orbiliales > Orbiliaceae > Drechslerella

Accessions

  • Primary accession
    W7IAA8

Proteomes

Subcellular Location

Golgi apparatus, trans-Golgi network membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Prevacuolar compartment membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1373-1394Helical
Transmembrane1420-1443Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_500489340423-1486Vacuolar protein sorting/targeting protein 10

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain45-686VPS10
Domain723-1360VPS10
Region1467-1486Disordered
Compositional bias1472-1486Acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,486
  • Mass (Da)
    167,240
  • Last updated
    2014-04-16 v1
  • Checksum
    D117CFBA5694887A
MRLLRSLPFLVALLGVTPKIHAGEPIVKTTSFTNLPLEYFYFEDSPCILSFDSVEGTIFRSEDSGATWSPIKQGEGRAWDLYQHPFDNTKAYILTTGTKHFKTEDRGKTWQEWDSIDLPSNHQPPLPALNFHSGKGKSDYIILLAQYCEDEFDVIIGNCLQNAYYTKDNFKTKPQKLLDHTHGCTFAHSSKQFDSATDDTVLCIVEGKESIMSEQRRLYISENYFKGGLDGAIEPKLDGQSTYQGVTGIAVVQKFLVVAVKSSGTTEMALFVSVNAKDWERSEFPSENGKVEQDAYTILESLPSSLQVDVLTTKASNAIGSLFSSNSKGTQFVRILENTNRNGRGLVDWESILNIEGIILANVVANAKELANKATGAKKIQSRISFDNGRTWNSLKAGGKTLHLHSVSDLANLGRVYSSPAPGMVMGIGNTGEYLRDYMEGDLYVSEDAGLTWKMSREGAHKYEFGDQGSILVAVNDEEKTDEVIYSLDHGDTWKTVNIGMKIRTRLLTTTPDSTSTKFTLVGIGPRDKDKKQYYIIHLDFSEVRSRTCKEDKSGKGDFEKWYARLDEDGKPDCLLGRKQYFWRRKKTADCFINSLYKEQLPEREICKCTEEDYECDTNFYRANGELKDDCVPRNAKFDDKGMCSKPENTFKGPSGYRLIPGDNCEKDGGKVLDNEKDRPCSDITTPAPAHGKISIKSKSFSGEMYLEQFYIERAESSSGSDETVVIRTRDGSIWLTHDQGENWEQPSELKNKEIVAIYPNPYIHDRLYFITPSEEVIYTHDRGKTYKTMKAPGPPNGLSIDVINFHPMHKDYMIWTSQKDCPGKDCHAVAHYTTDETTEWRTLLGYVRYCRWIANKYMDAKRVDKNMIFCERYVNDDTRGALELVTSDSFFTKETVQFSNIKGFATMEEFINVAVVDEQHSTLNVKASLDGKTFAAAQFPSGFEVPHQHAYTVLESITHAIYLHVTVNNAAGKEYGAILKSNSNGTDYVMSLPNVNRDGEGYVDFERMQGLEGVALANIVTNINDVNQGAAKKYRSMITHNDGGRWTFISPPSKDSKGKSYSCNTNNLEKCSLNLHGYTERPDKRHTYSSATAVGMMLAVGNVGEELLPMKDGDTFITRDGGISWTEIRKGAYMWEYGDQGSIIVVVKQDEPTKSIYYTTDEGHNWEEYVFSTSEVNVFDISSVPSDTSRKFIVWSKENGANKFTANSLDFSSLTNKKCVLSADATSDDDDFELWKPSHPEMEDGCLFGHQAVYARKIPDHKCYIGTRIPQPHKMYNNCTCTRHDYECDYNYEMKNDGTCKLVAGLQPLDPAQECITNPDLNQWFEVTGYRKVPLSTCNREGGVNLDETRAHSCPGKEDWFRKKHGSGIGSVGIFFLTVLSFCMAGLLGYVLWQRWPGKLGAIRLGDDRHQQESPFIKYPVIILSAVVAVAVSIPAVLGALYRMIANRFQRRPRYTTRGSFARDDYNNVDTDEGELLGEDSDDEV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1472-1486Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KI966422
EMBL· GenBank· DDBJ
EWC45975.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp