W7D448 · W7D448_9LIST

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site815-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1065-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site133-1415-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site196uracil (UniProtKB | ChEBI)
Binding site201-203uracil (UniProtKB | ChEBI)
Binding site2025-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      BCAMP_06430

Organism names

Accessions

  • Primary accession
    W7D448

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    211
  • Mass (Da)
    22,821
  • Last updated
    2014-04-16 v1
  • Checksum
    D9197DB5A312F7E2
MGKGKVTVMDHPLIQHKLTIIRDKATGTKVFREVADEIAMLMAYEITRDLELEDTMVETPVVTAKAKTLTGKKLGVVPILRAGLGMVEGVVKLIPAAKVGHIGMYRDEKTFEPVEYFIKMPSDINERTLIVVDPMLATGGSAILAIDALKKRGATNIKFMCMVAAPEGVKALTDKHPDVDVFIAALDEGLNEDGYIVPGLGDAGDRLFGTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AODH01000022
EMBL· GenBank· DDBJ
EUJ40058.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp