W7CTH4 · W7CTH4_9LIST

Function

function

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site13ADP (UniProtKB | ChEBI)
Binding site13ATP (UniProtKB | ChEBI)
Binding site13sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site14ATP (UniProtKB | ChEBI)
Binding site15ATP (UniProtKB | ChEBI)
Binding site17ADP (UniProtKB | ChEBI)
Binding site83glycerol (UniProtKB | ChEBI)
Binding site83sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site84glycerol (UniProtKB | ChEBI)
Binding site84sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site135glycerol (UniProtKB | ChEBI)
Binding site135sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site245glycerol (UniProtKB | ChEBI)
Binding site245sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site246glycerol (UniProtKB | ChEBI)
Binding site267ADP (UniProtKB | ChEBI)
Binding site267ATP (UniProtKB | ChEBI)
Binding site310ADP (UniProtKB | ChEBI)
Binding site310ATP (UniProtKB | ChEBI)
Binding site314ATP (UniProtKB | ChEBI)
Binding site411ADP (UniProtKB | ChEBI)
Binding site411ATP (UniProtKB | ChEBI)
Binding site415ADP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionglycerol kinase activity
Biological Processglycerol catabolic process
Biological Processglycerol-3-phosphate metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol kinase
  • EC number
  • Alternative names
    • ATP:glycerol 3-phosphotransferase
    • Glycerokinase
      (GK
      )

Gene names

    • Name
      glpK
    • ORF names
      BCAMP_06095

Organism names

Accessions

  • Primary accession
    W7CTH4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue231Phosphohistidine; by HPr

Post-translational modification

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.

Keywords

Interaction

Subunit

Homotetramer and homodimer (in equilibrium).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-252Carbohydrate kinase FGGY N-terminal
Domain262-450Carbohydrate kinase FGGY C-terminal

Sequence similarities

Belongs to the FGGY kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    497
  • Mass (Da)
    55,026
  • Last updated
    2014-04-16 v1
  • Checksum
    58AA196867A6C97D
MEKKYILAIDQGTTSTRAMLLNKQGKILGTEQREFTQHFPESGWVEHDANEIWSSVLATMSGVLVKTGVNAQEIAGIGITNQRETAVVWDKATSKPIYHAIVWQSRQTVDICTDLKAKGYEKMVTDKTGLLLDPYFAGTKVRWILDHVDGAQERAEKGELAFGTIDTWLIWKLSGGKVHVTDYSNASRTLMYNIYDLKWDEELLEMLNVPAAMLPEVHDSSHVYGHTVGYHFFGLETPIAGVAGDQQAALFGQGCFEKGMGKNTYGTGGFLLMNTGDKAIKSQNGLLTTLAWGINGKVSYALEGSIFVAGSALQWLRDGLRMVKTAPETEEYATRVDSTEGVYVVPAFVGLGAPYWDAEARGAVFGLTRGTTKEHFIRATLESLAYQTRDVIDSMEKDSGIKLETLRVDGGASANNFLMQFQSDLLQVPVERPENKETTVLGAAFLAGLAVGFWKDKEEINQYWSLEHKFEPVAGTEKEELLYEGWQKAVKATQVFK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AODH01000022
EMBL· GenBank· DDBJ
EUJ39995.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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