W7CDE6 · W7CDE6_9LIST
- ProteinDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
- GenepyrK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids254 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD+.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FAD per subunit.
Note: Binds 1 [2Fe-2S] cluster per subunit.
Note: Binds 1 [2Fe-2S] cluster per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 50-53 | FAD (UniProtKB | ChEBI) | ||||
Sequence: RPIS | ||||||
Binding site | 67-69 | FAD (UniProtKB | ChEBI) | ||||
Sequence: IYR | ||||||
Binding site | 74-75 | FAD (UniProtKB | ChEBI) | ||||
Sequence: GT | ||||||
Binding site | 217 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 222 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 225 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 241 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | electron transfer activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Listeriaceae > Brochothrix
Accessions
- Primary accessionW7CDE6
Proteomes
Interaction
Subunit
Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-99 | FAD-binding FR-type | ||||
Sequence: MRIEQMTVIQQKEIAERVYELILAGEMVTEMEAGQFINIKPTRSDLLLRRPISVAKIDKAQRQCTIIYRVDGEGTQTFADVKVGDLLDVIGPLGKGFPV |
Sequence similarities
Belongs to the PyrK family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length254
- Mass (Da)27,602
- Last updated2014-04-16 v1
- ChecksumD2C2066234F8C12A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AODH01000041 EMBL· GenBank· DDBJ | EUJ37354.1 EMBL· GenBank· DDBJ | Genomic DNA |