W7CDE6 · W7CDE6_9LIST

Function

function

Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD+.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster per subunit.
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site50-53FAD (UniProtKB | ChEBI)
Binding site67-69FAD (UniProtKB | ChEBI)
Binding site74-75FAD (UniProtKB | ChEBI)
Binding site217[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site222[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site225[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site241[2Fe-2S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Functionelectron transfer activity
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
  • Alternative names
    • Dihydroorotate oxidase B, electron transfer subunit

Gene names

    • Name
      pyrK
    • ORF names
      BCAMP_09995

Organism names

Accessions

  • Primary accession
    W7CDE6

Proteomes

Interaction

Subunit

Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-99FAD-binding FR-type

Sequence similarities

Belongs to the PyrK family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    254
  • Mass (Da)
    27,602
  • Last updated
    2014-04-16 v1
  • Checksum
    D2C2066234F8C12A
MRIEQMTVIQQKEIAERVYELILAGEMVTEMEAGQFINIKPTRSDLLLRRPISVAKIDKAQRQCTIIYRVDGEGTQTFADVKVGDLLDVIGPLGKGFPVEETLAGETAMLIGGGIGVPPLYEVACELKAKGAEVVTVLGFNSEDAVFYEEKFAALGDVHVATADGSHGTKGFVTTIMDDIPEADTYYSCGPTPMLRVLNDRLLTKRAFISLEERMACGIGACYACVCHKADGDRNESKKICVDGPVFKTGEVEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AODH01000041
EMBL· GenBank· DDBJ
EUJ37354.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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