W7BAQ4 · W7BAQ4_9LIST

Function

function

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site65glycerol (UniProtKB | ChEBI)
Binding site65sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site66glycerol (UniProtKB | ChEBI)
Binding site66sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site117glycerol (UniProtKB | ChEBI)
Binding site117sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site227glycerol (UniProtKB | ChEBI)
Binding site227sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site228glycerol (UniProtKB | ChEBI)
Binding site249ADP (UniProtKB | ChEBI)
Binding site249ATP (UniProtKB | ChEBI)
Binding site292ADP (UniProtKB | ChEBI)
Binding site292ATP (UniProtKB | ChEBI)
Binding site296ATP (UniProtKB | ChEBI)
Binding site393ADP (UniProtKB | ChEBI)
Binding site393ATP (UniProtKB | ChEBI)
Binding site397ADP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionglycerol kinase activity
Biological Processglycerol catabolic process
Biological Processglycerol-3-phosphate metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol kinase
  • EC number
  • Alternative names
    • ATP:glycerol 3-phosphotransferase
    • Glycerokinase
      (GK
      )

Gene names

    • Name
      glpK
    • ORF names
      PGRAN_10388

Organism names

Accessions

  • Primary accession
    W7BAQ4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue213Phosphohistidine; by HPr

Post-translational modification

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.

Keywords

Interaction

Subunit

Homotetramer and homodimer (in equilibrium).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-234Carbohydrate kinase FGGY N-terminal
Domain244-432Carbohydrate kinase FGGY C-terminal

Sequence similarities

Belongs to the FGGY kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    479
  • Mass (Da)
    53,202
  • Last updated
    2014-04-16 v1
  • Checksum
    935C28F0D4544DD7
MIVDETGEIIGVEQKEFEQIFPKPGWVEHNANEIWASILAVIAGVLLKTNISSKDIAGIGITNQRETTVVWEKESGNPIYNAIVWQSRQTADICNQLKKDGYNDIVRDKTGLLIDAYFAGTKARWILDHVDGAQERAENGELLFGTIDTWLVWKLTGGKAHVTDYSNASRTLLYNIYDLQWDDELLEMLNIPKVMLPEVRQSSEVYGTTVPYHFFGEEVPVAGIAGDQQAALFGQGCFEKGEAKNTYGTGCFLLMNTGDKAVKSDTGLLTTLAWGIDGKVEYALEGSIFVAGSAIQWLRDGMRMLRHSGDSENYASRIESSDGVYVVPAFVGLGAPYWDSDVRGAVFGLTRGTEKEQFIRATLESLAYQTKDVLDAMEKDSGIELKLLHVDGGACANDFLMQFQADILNVPVERPENRETTVLGAAFLAGLAVGVWKDRKEIKRHWKLDKKFEVEMKEEERAALYGGWKKAVKAAQAFK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AODD01000014
EMBL· GenBank· DDBJ
EUJ23087.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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