W6KXY8 · W6KXY8_9TRYP

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site26substrate
Site26Important for catalytic activity
Binding site261substrate
Site261Important for catalytic activity
Binding site353substrate
Binding site380substrate
Binding site459substrate
Binding site467substrate
Binding site471substrate
Binding site518substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • ORF names
      GSHART1_T00000028001

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hart1
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Phytomonas

Accessions

  • Primary accession
    W6KXY8

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain350-524Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    667
  • Mass (Da)
    72,575
  • Last updated
    2014-04-16 v1
  • Checksum
    D73C8BFB91656831
MASALEVANCIRCLAADIVQGAKSGHPGTPMGMAPVATVLWTEVMSYLGSDPSWPDRDRFVLSNGHGCALLYSLLHMSGYALGMDELKRFRQIGSRTPGHPERGWTPGVEVTTGPLGQGIANAVGLAIAEANLAGTFNRPELDIVNHWTYVFCGDGCLMEGICVEALSLAGHLCLEKLVVVYDSNQITIDGSTSLAFTEKVRQKHESMNFHVIEVDNADNDFTALRNAFTEAKSVRGKPKFILIKTTIGYGSKLQGTEKVHGAPLGDEDIAVLKRKFGRDPSKKYYIDDAVYEVFRKHAQKCEQTHREWDEKMAKYTKQYPKEAAAFKARMKGELPTGWDATLPLNDKPVATRKASENCLAALLPALPFIIGGSADLTPSNLTHPASANLCDFTPLTPEGQYVRFGVREHGMLGIANGIDAHGGLLPYTGTFLTFFGYGLGALRLAALSHHHVIYVATHDSVGLGEDGPTHQPVEIVAMLRAIPNLLVFRPTDQTETSGAWAAAIRAQHRPSILCLSRQNTTPQPTSSLEGVEKGAYPLREVENPQLLILSSGAEVGIAMEAVALLSDLRVGVVSMPCQELFEEQPRRYRESVIPNGIPVISVEPYVSFGWERYSHVHVGMTGFGASAPGEVLFKHFNITPEKVAEVGRKLIERFPNGTAPLKTCHL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HF955199
EMBL· GenBank· DDBJ
CCW65923.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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