W6K9P7 · W6K9P7_MAGSQ

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site19Nucleophile
Binding site254[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site301Mg2+ (UniProtKB | ChEBI)
Binding site363Mg2+ (UniProtKB | ChEBI)
Binding site364Mg2+ (UniProtKB | ChEBI)
Binding site400[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site456[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site459[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • ORF names
      MGMAQ_2181

Organism names

Accessions

  • Primary accession
    W6K9P7

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain19-238Glutamine amidotransferase type-2
Region467-488Disordered

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    488
  • Mass (Da)
    53,338
  • Last updated
    2014-04-16 v1
  • Checksum
    638F3F3694FB8891
MSDSPMDQFLPDDRPREECGVFGIYGHKDAAQLTALGLHALQHRGQEAAGVVTCDQGHFYTHRALGLVGDHFSSQAVMDPLVGQMAIGHVRYSTTGDTLLRNVQPIFADFAFGGMAIAHNGNLTNARAVRKTLVARGCLFQSTMDTEIIIHLVAISLYTTVVDRMIDALRQLEGAYSLVALTRKKLIGVRDPLGVRPLVIGKLGDSLILTSETCALDIIGAEFIRDVEPGEIVVIDENGLRSIKPFGSSKQRFCIFEYVYFARPDSVMEGHNVYGVRKQIGKELARESHVEADMIVPVPDSGVPAALGYAEESGIPFDLGIIRNHYVGRTFIEPTDRIRHLGVRLKHNANAAYLAGKRVVLVDDSIVRGTTSIKIVEMVRSAGAAEVHMRISSPPTNNSCFYGIDTPKKEQLLASQMDLEAMAKHIGVDSLAFLSFDGLYRAVGESGRDPESPCYCDACFTGEYPTKLTDHSDSNGMPEQLTLLTESR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO538765
EMBL· GenBank· DDBJ
CCQ74070.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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