W5ZWG2 · W5ZWG2_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3898 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Acts as a cofactor for the NS3 protease activity.
Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.
Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Also plays a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.
Plays a role in the regulation of viral RNA replication.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 49 | For N-terminal protease activity | |||
Active site | 69 | For N-terminal protease activity | |||
Site | 168-169 | Cleavage; by autolysis | |||
Active site | 1658 | Charge relay system; for serine protease NS3 activity | |||
Active site | 1695 | Charge relay system; for serine protease NS3 activity | |||
Active site | 1752 | Charge relay system; for serine protease NS3 activity | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Pestivirus > Pestivirus suis
Accessions
- Primary accessionW5ZWG2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Peripheral membrane protein
Virion membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 1031-1055 | Helical | |||
Transmembrane | 1076-1095 | Helical | |||
Transmembrane | 1115-1133 | Helical | |||
Transmembrane | 1145-1164 | Helical | |||
Transmembrane | 1189-1208 | Helical | |||
Transmembrane | 1220-1238 | Helical | |||
Transmembrane | 1250-1271 | Helical | |||
Transmembrane | 1283-1304 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer; disulfide-linked. Heterodimer with E1; disulfide-linked.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-168 | Peptidase C53 | |||
Region | 170-204 | Disordered | |||
Compositional bias | 173-204 | Basic and acidic residues | |||
Region | 221-242 | Disordered | |||
Domain | 1441-1589 | Peptidase C74 | |||
Domain | 1590-1763 | Peptidase S31 | |||
Domain | 1802-1960 | Helicase ATP-binding | |||
Domain | 1978-2179 | Helicase C-terminal | |||
Domain | 3519-3642 | RdRp catalytic | |||
Sequence similarities
Belongs to the pestivirus polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,898
- Mass (Da)437,951
- Last updated2014-04-16 v1
- MD5 Checksum0D5BEA8A1DB4600BC79F21ABBD0413D3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 173-204 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF977609 EMBL· GenBank· DDBJ | AHI46591.1 EMBL· GenBank· DDBJ | Genomic RNA |