W5X2R1 · W5X2R1_CHV16

Function

function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site415substrate
Binding site430-431substrate
Site431Important for hydrogen atom transfer
Binding site461substrate
Active site639Proton acceptor
Binding site639-643substrate
Active site641Cysteine radical intermediate
Active site643Proton acceptor
Site656Important for hydrogen atom transfer
Binding site816-820substrate
Site959Important for electron transfer
Site960Important for electron transfer
Site980Interacts with thioredoxin/glutaredoxin
Site983Interacts with thioredoxin/glutaredoxin

GO annotations

AspectTerm
Cellular Componentribonucleoside-diphosphate reductase complex
Molecular FunctionATP binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process
Biological ProcessDNA replication
Biological Processviral process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonucleoside-diphosphate reductase large subunit
  • EC number
  • Short names
    R1
  • Alternative names
    • Ribonucleotide reductase large subunit

Gene names

    • Name
      UL39
    • Synonyms
      RIR1

Organism names

Accessions

  • Primary accession
    W5X2R1

Proteomes

PTM/Processing

Keywords

Expression

Keywords

Interaction

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-22Disordered
Region109-170Disordered
Domain794-816Ribonucleotide reductase large subunit

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    985
  • Mass (Da)
    109,588
  • Last updated
    2014-04-16 v1
  • Checksum
    A01D0EE1E41052EE
MSEFRVSAADGAPADEPAPTPIRQPRRFLYCDRVSGLTVAADGTPSCHITNSRFVQCGSNCAMVVDGTAGAATTATGADPDARAEVAVVSFVAPPARPGAMVSIATQTDDPLTPAAPASPTPTPDPTPTSESGEQAPDARPSSATGGPAAGEEPAADDEPPRPPSAFPVPLELNHKNAEAMARFLGDAGERDPTLLLNYFCRCAREAEERSAGPRTFATEPTLGYREFGLLRYAIYELQRMFVDVPPMPHAAWTPVRFAEYVTQLVNKFKPLVRRSDRLYRLLGMLVHLRIRCRSVSFEWWLRSREIGLDEELVERLRDHESQLVPFFEGLERGPTMRLMERGLQSALKYEEFYLKNIDGWLLESVPQMYTRIAGYLACHSDLAGRVVFGRDASWLEMFTYFFNRFYAHEIVPSTPAMLGLGTRRPYMSSCYLVNPQTRTAHSTLAAITQNVAPILARSGGIGLCLQNFNDRPGNASLMPALKALDSIVAAYNDQSLRPTGVTVYLEPWHSDIMAVLRMKGVLAGEEARRCDNIFSALWMPDLFFKRLIRYLEGEKDVVWTLFSHRGGMHLASFHGEKFERLYRGQEEMGFGEAVPIQDVAYAIVRAAATTGSPFVMFKDAVNRHYIYDTQGSAIAGSNLCTEIVHPADAQQSGVCNLASVNLAECVVGRTFDFARLRESVRACVLMVNIMIDRTAQPTPQCRRGHDRLRSMGIGMQGLHTACLKMGLDLASEEFRELNRHIAEVMLLAAMQASNALCFHGARPFREFKRSVFRAGRFHWEGFPDARPRYEGEWEMLRQSMMKHGLRNSQFIALMPTVASAQLADVSEGFAPLFTNMFSKVTRDGETLRPNTLLLRELRETFSGRRLNEVIDSLDAKQWSVERALPCLAADHPLRRFKTAFEYDQELLIDLCADRAPYVDHSQSLTLYVTERADGTLPASSLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFGGDDNIVCTSCVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF790626
EMBL· GenBank· DDBJ
AHI07426.1
EMBL· GenBank· DDBJ
Genomic DNA
KF790628
EMBL· GenBank· DDBJ
AHI07428.1
EMBL· GenBank· DDBJ
Genomic DNA
KF908241
EMBL· GenBank· DDBJ
AHM96161.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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