W5JJA9 · W5JJA9_ANODA

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      AND_003806

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    W5JJA9

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane61-78Helical
Transmembrane98-120Helical
Transmembrane132-156Helical
Transmembrane162-183Helical
Transmembrane190-210Helical
Transmembrane230-252Helical
Transmembrane282-305Helical
Transmembrane325-342Helical
Transmembrane349-368Helical
Transmembrane374-399Helical
Transmembrane406-429Helical
Transmembrane435-459Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-27Disordered
Domain63-464Major facilitator superfamily (MFS) profile
Region487-510Disordered

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    536
  • Mass (Da)
    59,497
  • Last updated
    2014-03-19 v1
  • Checksum
    2BEC502645AC8C8C
MPRPYEEDEARQPILQQADTDTDEPSTARLIRRSDDDELSERLTGCGATACCNPNSALHRFQALILMCLVGFGSYFCYDNPGALQDTFKSDLDLTTTQFVMLYSIYSWPNVILCFIGGFLMDRVFGIRLGTIIYMFILLIGQLIFAMGATINMFWLMIVGRFLFGIGAESLAVAQNSYAVLWFKGKELNMVFGLQLSFARVGSTVNFLVMVPIYKYVKSLGYQGHMCTGVVLLLATLTCVMSMFCALILGWMDRRAARLTKRNDSAPGGEVAKLSDVRTFKVSFWMVTVICVAYYVAIFPFIALGKVFFMRKYDFSAEDANTVNSIVYIIAAVASPVFGLVVDRFGRNVLWVFLSVTVTIIAHGMLAFSHLNPYIGMITMGLAYSMLASSLWPLVALIVPEYQLGTAYGICQSVQNLGLAVISMISGMIVDKGGYFMLEIFFIGWLIVSLLATIVIWLYDASNDGILNMSPAGRELYASKSLQRSSTDIAGSSSDSTDGGRLERERRAKDPEVIRNRYVNRVLDATPTQSESDLVE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADMH02001016
EMBL· GenBank· DDBJ
ETN64447.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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