W4VSP6 · W4VSP6_MOUSE
- ProteinNeutral cholesterol ester hydrolase 1
- GeneAadacl2fm2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids401 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+This reaction proceeds in the forward direction.
- a cholesterol ester + H2O = a fatty acid + cholesterol + H+This reaction proceeds in the forward direction.
- cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 189 | |||||
Sequence: S | ||||||
Active site | 341 | |||||
Sequence: D | ||||||
Active site | 371 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | plasma membrane | |
Molecular Function | carboxylic ester hydrolase activity | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameNeutral cholesterol ester hydrolase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionW4VSP6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 5-23 | Helical | ||||
Sequence: ILCFGLFCILFAYYIYIPM |
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 107-257 | Alpha/beta hydrolase fold-3 | ||||
Sequence: VIFIHGGAFTLGSCKMLPYDYLNRWTANKLDAVVVGIDYRLAPQYPFPAALEDCVLVIKYFLQDTILKKYGVDPTRICISGDSCGGTLATTAIQLLQNNPEHKDKIKAQALLYPGLQFIDTLMPSHRINEHGPFLSREIAIKLAYLYVTED | ||||||
Domain | 290-374 | Alpha/beta hydrolase fold-3 | ||||
Sequence: KYKKNYVYTEPTLGKLNVFYPALLDSRLSPLLVNDSQLQSLPLTYILTCEHDILRDDGLIYSTRLRNVGVQVTHDHIEDGIHGAI |
Sequence similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length401
- Mass (Da)46,010
- Last updated2014-03-19 v1
- Checksum6A0A2BD8839640FB
Keywords
- Technical term