W4VS99 · NEP_TRILK
- ProteinNeprilysin-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids722 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 552 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 553 | ||||
Binding site | 556 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 614 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 618 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | protein processing |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNeprilysin-1
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Araneae > Mygalomorphae > Barychelidae > Trittame
Accessions
- Primary accessionW4VS99
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-17 | ||||
Chain | PRO_0000429203 | 18-722 | Neprilysin-1 | ||
Disulfide bond | 33↔38 | ||||
Disulfide bond | 56↔707 | ||||
Disulfide bond | 64↔667 | ||||
Glycosylation | 100 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 120↔378 | ||||
Glycosylation | 184 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 207 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 424 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 589↔719 | ||||
Glycosylation | 609 | N-linked (GlcNAc...) asparagine | |||
Post-translational modification
Contains 5 disulfide bonds.
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom gland.
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length722
- Mass (Da)82,056
- Last updated2014-03-19 v1
- Checksum25BBD6BE9140774B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GAQE01000047 EMBL· GenBank· DDBJ | JAB84507.1 EMBL· GenBank· DDBJ | Transcribed RNA |