W4VS99 · NEP_TRILK

Function

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1722100200300400500600700
Type
IDPosition(s)Description
Binding site552Zn2+ (UniProtKB | ChEBI); catalytic
Active site553
Binding site556Zn2+ (UniProtKB | ChEBI); catalytic
Binding site614Zn2+ (UniProtKB | ChEBI); catalytic
Active site618Proton donor

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    W4VS99

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_000042920318-722Neprilysin-1
Disulfide bond33↔38
Disulfide bond56↔707
Disulfide bond64↔667
Glycosylation100N-linked (GlcNAc...) asparagine
Disulfide bond120↔378
Glycosylation184N-linked (GlcNAc...) asparagine
Glycosylation207N-linked (GlcNAc...) asparagine
Glycosylation424N-linked (GlcNAc...) asparagine
Disulfide bond589↔719
Glycosylation609N-linked (GlcNAc...) asparagine

Post-translational modification

Contains 5 disulfide bonds.

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-722Peptidase M13

Sequence similarities

Belongs to the peptidase M13 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    722
  • Mass (Da)
    82,056
  • Last updated
    2014-03-19 v1
  • Checksum
    25BBD6BE9140774B
MAVALLVALCVVSSRMALPSEAVPFYRQDSEVCNSPVCQKAAQTLLESMDTSVDPCQDFYQYACGEWIRKHPIPEEKFRISPLDALYDNVLDTVAEILKNATSENHATSVLKSANYFQACMDAEARETQGVEPLKNLLTSLGGWPMATPGWSGANYHWQTQVATVTRNLGIRPIIDVFVDADANRTSQHIINLDQADFGLGRNQLINLTSSSRTQEIVAGYRNYIIASAKLLNPNADDIQLANDADEIIQFESTLAQFSTPPEERRDASSWYHKMTVAEVQTVTENTYFQWTEFLNTVLKEFPQVMPETEVILYERDYTKNVLKLAHETNPRILANYIGWIVLMKEGYHTTRQFRENKFQFEKVQIGIEKEEKLERVCTDHTIGLLGYAVGRLYVDKFFTEEEKQDIDELVENIRSAYKSTLRNNTWMDHVTRNKAIDKLEAMINKMAYPTWIKNDNELNEYYRSVPAINRDEFFSSLLKVTKVVKAIQLGKWNKPTDRIKDWITTPAVVNAFYSPDSNSMSFPAGILNWPLYQYGTSPALNYGAIGAIIGHEMSHGFDDQGGQTDPEGNLVDWWLEETKAKFNQKADCFRKQYSSYLEPTTNMHLNGNNTVGENIADNGAVRNAFIAYKMHLLHSQNNHVMRKKTLPGLSATAEQLFFLGYSTMWCGAERKESLEWSIQYDSHTPSEFRAVVPLTNSRSFAEAFGCASGTPMNPTHKCLLW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GAQE01000047
EMBL· GenBank· DDBJ
JAB84507.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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