W4RNN4 · W4RNN4_9BACI

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site95Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site96Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site132substrate
Binding site158substrate
Site168-169Cleavage; by autolysis
Active site169Nucleophile
Binding site169substrate
Binding site255substrate
Binding site377substrate
Binding site382substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      JCM21738_2592

Organism names

Accessions

  • Primary accession
    W4RNN4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50233358651-168Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023335864169-382Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    382
  • Mass (Da)
    40,598
  • Last updated
    2014-03-19 v1
  • Checksum
    318F6F8BFDEA0778
MHAGLRYTKLDLGMIVSEKPASCAAVYTTSHFLAAPLVVTQESIEKEKILQAIVVNSACANACTGEQGYQDALKMRSLAAAKMGIPEHHVAVASTGVIGEFMQMEKIESGIGKLAIGKAAEDAKDFQTAILTTDTVMKSCCYSAEIDGITVSMGGLAKGSGMIHPNMATMLAFLTTDANISSEHLTAALKDVTNTTFNQITVDGDTSTNDMVLVLANGSAENQPLNPDHPDWAVFVELLKESCASLAKQIARDGEGATKLIEISVAGAMSDEEARMIGKQIAGSNLVKTAVYGADANWGRIIGAIGQSQAKVNPKTVDISLGEITMLKGSTPVTFDENQAREYLMNDKVEIFVDLHVGKGKGMAWGCDLSYDYVKINASYRT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BAUW01000028
EMBL· GenBank· DDBJ
GAE45752.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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