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W2SXV2 · W2SXV2_NECAM

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionguanylate cyclase activity
Molecular Functionpeptide receptor activity
Molecular Functionprotein kinase activity
Biological Processintracellular signal transduction
Biological Processprotein phosphorylation
Biological Processreceptor guanylyl cyclase signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Guanylate cyclase
  • EC number

Gene names

    • ORF names
      NECAME_12965

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Strongyloidea > Ancylostomatidae > Bunostominae > Necator

Accessions

  • Primary accession
    W2SXV2

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane589-616Helical
Transmembrane690-708Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_500482565123-1765Guanylate cyclase

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Domain601-938Protein kinase
Coiled coil947-978
Domain1010-1141Guanylate cyclase
Region1285-1318Disordered
Compositional bias1291-1318Polar residues
Region1436-1472Disordered
Compositional bias1441-1456Basic and acidic residues
Region1624-1655Disordered
Region1706-1747Disordered
Compositional bias1719-1747Polar residues

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,765
  • Mass (Da)
    200,368
  • Last updated
    2014-03-19 v1
  • MD5 Checksum
    1B4341AC54406D1BAC4636DD1F3FB3B3
MRDGFLVDLTLFILFLLRLLKCQTIDAPEPPPSVGALLDPNSTNDNEILISYLAAVSRLDEQPEEFMKAISIARTRGSDSSSSSSPFHDERFKQIYTMFNCFSTDFDGSMISGALHVAVNEINADPNLLPNHRLTYIFDNTCGKEKQSTQYFMDHWKMGARVFIGPEMNCRTEATMAAAQNLPIISYKCKDQTVSDKKKYNTFARTVPAETDIVKAFIALCREYSWKKFAIIYEEHPAHEELYLALRQAIDQENGRMDIDETRYSVQNVSKVIRFSEVQSEKLVDSVIEQTKDMTRLYVTFGNVRLFRKILMSMGKLGLTDSQQYLLIYLDPDYNWLNVYHAMNNHFFRNTMIDLESSWDVSNSSDHRIIGYSRAALAIIPTPVELNSARFKKFWEQAVKDLSNFGISKHEHTWSIKVNRFACYLYDAVYLYARALHELIEETSERQAHGYDPTRDGAAIINKILNRKYSSTGSVAFTKSLLIIELLIHTSFCHSLGMQGFDMRINEHGDAKGNYTLLSWQEVEPVKSKTDGNYYPLDHALDITAMFVDGGEGQNNMPELVFNKPILWIDGPTRDQPDCGFHGELCRDYGGYISVISLILFVIILIGGAISAGFVYRSRKFEKELAMIWKIEMGDHTWYTGQDAEKKGSGLRGVAYYKGTLVALKELTYSRKPRELTRQYKIEMRVMRQLTHPNINSFMGIIVCPYSICIVREFCAKGSLMDILQNREFKLDHLYVASFVEDLINGMVYLHDSELKVHGNLKSTNCLITSRWALQVADFGHHEIREGRQWENEESRWMSYLWCAPELLRESELKHSVKGTQKGDVYAFGIILHEILTRQGPFQIFAKSDTQVPVVLVFMHALSAIKFSISYPSLRFFLIFINSEIVARVAGGTCSRPNLSCIEGQDYVIETMRLCWSEYPENRPDFKNGIRQKLKPMFAGIYKRNIMDHMMVMMEKYQNQLEDLVDERTAELREEQKRSQHLLQRMLPRSVAQQLLDGQDVIPESFPSVTIYFSDIVGFTRISGESTPMQVVAFLNKLYTKFDRIIQKYDVYKVETIGDAYMVVSGVPNFKETQFHAKEIALMALRLLRAVRNFKIPHRPNEQLILRIGIHTGSCVAGVVGKTMPRYCLFGDTVNTASRMESNGEPLKIHCSQPTRDVLASIPGFVLEERGTLTIKGKGQMTTYWLLDAEGYEFSDDDDEQREEPSLAPEIFPRNSTFRTIRGSGFALNRESTVSLSTQKDQSFLKRFIGTVRPSAQANDSQCSAFYSALNGGVVSMGNSYKELPSVHEEDSPNASRQANNYNHRSVRRPPFSSTRNCYQHVNRSSFPTDSDVVLRKRSTSLPDGEVLNLDVVGPVTGANSTAPVSSYCSPCTRRNTAESRTMQSASPSPSQYPSYKDLADLPAIPRKQGMVFIVRPSRKRSLSVGDNVQHATPLSFEEDTSLKVDPDDPLISPPRKPRRQRRRFKSKDRKSLLSLQHLRDPSPLQRLRDASPFGRHLWNGGERTVNRFLRRLANGMGSQYIDLNNSTDDNSDYHSGTAVSKVPLLPKACEKEANDKDGQTDPLIPINSPLMLSLSFISVVNLIVVAAHMHVPNMPINKAENKLRQENEQRKDHSPLLQAILESRSSRDTSTGGSDSQRILPAASAANPPTDRGNLSSLQALLAAPFSSPRKRELTEQDLTEPVHSKNDVVLRALLDLPRLDERQRTEIIRDTSSDDENLSPETQSSSQHNEMQPLTMPQHDPSDNSTVTQIKLHLAYVFYQLAK

Features

Showing features for compositional bias, non-terminal residue.

Type
IDPosition(s)Description
Compositional bias1291-1318Polar residues
Compositional bias1441-1456Basic and acidic residues
Compositional bias1719-1747Polar residues
Non-terminal residue1765

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KI660359
EMBL· GenBank· DDBJ
ETN74465.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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