W1P9L6 · W1P9L6_AMBTC

  • Protein
    Methylenetetrahydrofolate reductase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Molecular Function3'-5' DNA helicase activity
Molecular FunctionATP binding
Molecular Functionfour-way junction helicase activity
Molecular Functionmethylenetetrahydrofolate reductase (NAD(P)H) activity
Molecular Functionnucleic acid binding
Biological ProcessDNA unwinding involved in DNA replication
Biological Processdouble-strand break repair via homologous recombination
Biological Processmethionine metabolic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylenetetrahydrofolate reductase

Gene names

    • ORF names
      AMTR_s00147p00086270

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Amborellales > Amborellaceae > Amborella

Accessions

  • Primary accession
    W1P9L6

Proteomes

Genome annotation databases

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil, compositional bias, region.

Type
IDPosition(s)Description
Domain617-782Helicase ATP-binding
Domain806-954Helicase C-terminal
Coiled coil1121-1152
Compositional bias1184-1199Polar residues
Region1184-1318Disordered
Compositional bias1200-1224Basic and acidic residues
Compositional bias1225-1272Polar residues

Sequence similarities

Belongs to the methylenetetrahydrofolate reductase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,318
  • Mass (Da)
    147,928
  • Last updated
    2014-03-19 v1
  • Checksum
    EAD88684FCBB84FA
MKVIEKIREAAKEDRTVFSFEFFPPKTEDGVENLFERMERMASHNPSFCDITWGAGGSTADLTLDISNKMQNMICVETMMHLTCTNMPVEKIDHALDTIKQNGIQNVLALRGDPPHGQDKFVQVAGGFACGLDLVAHIRAKYGDYFGITVAGYPEAHPDMISSEGGVTLENYLSDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVHDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPDEITKALEPIKDNEEAVRAYGVHLGTEMCKKILSHGIKTLHLYTLNMEKSALAILMNLGLIDESKISRPFPWRRPANVFRVKEDVRPIFWANRPKSYLSRTLGWEQYPHGRWGDSCNPSYGALTDYQFMRRRSRNKKILEEWAVPLKSVEDVKEKFTNYCLGKVKSHPWSELDGLQPETLMINEKLGQVNSKGFFTINSQPAVNGEKSDSPSVGWGGPGGYVYQKAYLEFFCSKEKLDALVENCKGLPSVTYIAVNKQGERVSNVGPIAVNAVTWGVFPAKEVLQPTVVDPVSFMVWKDEAFEIWNKGWGVLYPEGDPSKQILNELRFIRMEKLPLPISRVVDLKKKFFKREELLDILRHHFGHSDFRGRQLDAIEAVLCGKDCFCLMPTGGGKSLCYQVPAVAQKGITLENQVTALKKNGIRAEYLSSSQNPQAKEKIYEDLDSGRPSLRLLYVTPELIATNGFMYKLLKLHGRSLLQLIAVDEAHCISAWGHDFRPSYRKLSSLRKRLPGVPILALTATAVPKVQKDVIESLCMQHPLVLKASFNRPNIYYEVRYKDLLDDAYADLLTLLKTSGNVCSIVYCLERSTCDDLGARLLKDGIPCGVYHAGLNNKVRSRVLDDWLSSKTQVVIATIAFGMGIDRKDVRIVCHFNIPKSMEAFYQESGRAGRDQLPSKSVLYYGLEDRRKMEFVLRNAANSKGNKLNSQDHQIEKCLADFAQVVEYCEGSGCRRKKILGFFGEQVHGALCNKSCDACKHPNLLSKKLEELTHMSSTLSKNRLAPVFITGTSLMASDQGTEFWNRDDEVSCSEEDICDSDDEGLEICDSLAKNKSSTFQLNERVEHLLQAEENYNSRNSMNKQASGPGDKKAITETLREASIQRLQNSLKQAQDRLSESIMEVQIAAKVLENECYNKYRKTGKTFYISQVASTVRWLSSCSASELSNRLGSNSSKISCNTEHNSKEQEETIVSDRDERKNKVGVGGSKSNEDQSGEATILTNERDNKDGLGNPNSKTMEKTRTQDSQLPRIPSFSEFVGQKGKLGQSDHLGALSKRPTSSVSKKMEARSGSEKRIRLKD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1184-1199Polar residues
Compositional bias1200-1224Basic and acidic residues
Compositional bias1225-1272Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KI394278
EMBL· GenBank· DDBJ
ERN04379.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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