W1JCK0 · W1JCK0_SALDE

  • Protein
    Dihydropteroate synthase
  • Gene
    sul1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondihydropteroate synthase activity
Molecular Functionmetal ion binding
Biological Processfolic acid biosynthetic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydropteroate synthase
  • EC number
  • Short names
    DHPS
  • Alternative names
    • Dihydropteroate pyrophosphorylase

Gene names

    • Name
      sul1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 26
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    W1JCK0

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-255Pterin-binding

Sequence similarities

Belongs to the DHPS family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    276
  • Mass (Da)
    29,827
  • Last updated
    2014-03-19 v1
  • Checksum
    0E05DE21D88D01F8
MFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG314953
EMBL· GenBank· DDBJ
CDL93473.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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