W0Z8A4 · W0Z8A4_9MICO

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site15-20NAD+ (UniProtKB | ChEBI)
Binding site18NADPH (UniProtKB | ChEBI)
Binding site19NADPH (UniProtKB | ChEBI)
Binding site39NADPH (UniProtKB | ChEBI)
Binding site40NADPH (UniProtKB | ChEBI)
Binding site56NADPH (UniProtKB | ChEBI)
Binding site114NADPH (UniProtKB | ChEBI)
Binding site114sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site114substrate
Binding site144sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site148NAD+ (UniProtKB | ChEBI)
Binding site148NADPH (UniProtKB | ChEBI)
Active site199Proton acceptor
Binding site199sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site252sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site262sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site263NAD+ (UniProtKB | ChEBI)
Binding site263NADPH (UniProtKB | ChEBI)
Binding site263sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site263-264substrate
Binding site264sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site289NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      MIC448_2030003

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C448
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Microbacterium

Accessions

  • Primary accession
    W0Z8A4

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain10-168Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain188-327Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Region321-353Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    375
  • Mass (Da)
    39,569
  • Last updated
    2014-03-19 v1
  • Checksum
    4462B72E4423132D
MSRKAPDGPKVAVIGAGSWGTTFGKILADGGAAVTMWARRPELAHEIAEGKRNSEYLPGVNLPRSMTATAHLSEALDGATQIYLSVPSQALRESLKAVRPLVADNDALLISLMKGVERRSGMRMSQVIEQELACDPARIAVASGPNLALEIAREQPTAAVISSTSQETADAVARRARNAYFRSFVNTDVIGTEFGGVLKNLIAVAIGIVDGVGYGENTKASIITRGLVEMTDFAVAYGAQPETLQGLAGLGDLIATCQSPLSRNNTAGRLLGQGYSFQDVVKQMQQTAEGLASVAPVLQLAKEVGVEMPIVEQVKRVLDGTMKPQQIAPHLTTDDDTPRGERTQNAQTGGGGALWRSLQRALDQLRNGGRGAAGD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CBVQ010000117
EMBL· GenBank· DDBJ
CDK00008.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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