W0Z4W2 · W0Z4W2_9MICO

Function

function

Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-19NADP+ (UniProtKB | ChEBI)
Binding site106NADPH (UniProtKB | ChEBI)
Binding site191L-homoserine (UniProtKB | ChEBI)
Active site206Proton donor

GO annotations

AspectTerm
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processisoleucine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homoserine dehydrogenase
  • EC number

Gene names

    • Name
      hom
    • ORF names
      MIC448_1130004

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C448
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Microbacterium

Accessions

  • Primary accession
    W0Z4W2

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain358-440ACT

Sequence similarities

Belongs to the homoserine dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    441
  • Mass (Da)
    45,448
  • Last updated
    2014-03-19 v1
  • Checksum
    C03B79B479637994
MTDYRTLRVALLGAGAVGSQVAGLLLRHGDELADRAGARLELAGIAVRDVDAPRDVDLPRELFTTDAESLIVGSDIVIELMGGLEPARTSILHALSSGADVVTANKALLATHGAEIYDAADQVGASVYYEAAAAGAIPIIRPLRDSLAGDRVRRIMGIVNGTTNYILDRMDTEGADFAEVLADAQRLGYAEADPTADVEGYDAAQKAAILASLAFHTSVPLDTVHREGITSVDAALIESARHAGYVVKLLAVCERIEDASGAGPAEAISVRVYPALVPRTHPLASVHGANNAVFVEAEAAGSLMFYGAGAGGVQTASAVLGDVVSAARHHIAGGVGVGESTRANLPILPIGRVTTRYQITLEVSDETGVLATVAGILSEGRVSIATVEQTVVADPDGGPGIARIVIGTHKALEQDLSDTVARLAASGVVERVVSVLRVEGD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CBVQ010000017
EMBL· GenBank· DDBJ
CDJ99045.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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