W0Z4W2 · W0Z4W2_9MICO
- ProteinHomoserine dehydrogenase
- Genehom
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids441 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.
Catalytic activity
- L-homoserine + NAD+ = H+ + L-aspartate 4-semialdehyde + NADHThis reaction proceeds in the backward direction.
Cofactor
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | homoserine dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | isoleucine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomoserine dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Microbacterium
Accessions
- Primary accessionW0Z4W2
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 358-440 | ACT | ||||
Sequence: QITLEVSDETGVLATVAGILSEGRVSIATVEQTVVADPDGGPGIARIVIGTHKALEQDLSDTVARLAASGVVERVVSVLRVEG |
Sequence similarities
Belongs to the homoserine dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length441
- Mass (Da)45,448
- Last updated2014-03-19 v1
- ChecksumC03B79B479637994
Keywords
- Technical term