W0T6B6 · ATG14_KLUMD

Function

function

Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (By similarity).
This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (By similarity).
ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity).

Miscellaneous

Kluyveromyces marxianus proteins are shorter in length and have a more ordered secondary structure than their S.cerevisiae counterparts, which might contribute to the superior thermotolerance and solubility (PubMed:26442587).
K.marxianus could be therefore useful as a new model organism for further elucidation of the molecular details of autophagy (PubMed:26442587).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentphagophore assembly site membrane
Cellular Componentprotein-containing complex
Cellular Componentvacuolar membrane
Biological Processmacroautophagy
Biological Processprotein transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 14

Gene names

    • Name
      ATG14
    • ORF names
      KLMA_20709

Organism names

Accessions

  • Primary accession
    W0T6B6

Proteomes

Organism-specific databases

Subcellular Location

Preautophagosomal structure membrane
; Peripheral membrane protein
Vacuole membrane
; Peripheral membrane protein

Keywords

Phenotypes & Variants

Disruption phenotype

Still forms preautophagosomal structures (PAS) in proximity to the vacuolar membrane (PubMed:26442587).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004439111-305

Interaction

Subunit

Component of the autophagy-specific VPS34 PI3-kinase complex I (By similarity).

Structure

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil34-147

Domain

Coiled-Coils at the N-terminal half are essential for autophagy (By similarity).

Sequence similarities

Belongs to the ATG14 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    35,265
  • Last updated
    2014-03-19 v1
  • Checksum
    ED8DAB9EF6EA0B0A
MIHCGICGKAKTADVQFICCHCINGSPAVLLRDKMNLLILRQEVEQLKTAVEDQLETGFAGEGQLGRQLQKLDIYNEKRRLIKLRQRLQLARNKVQLKRNKYNELLQIMSTNGYLEESTSATDSIDLEEQAAEESASLDTLSHILARNQKQLFAELCRWFRIRKSDEDDVFSYTIWGLPMVNLKNGSELDPSIMVSSMRYLQQYLQLAFRIWLFKAICDKPIENDRNIIENFTQLIYDTLDILRARKLVSKSVSIRDILIRYDLDGMIYHLSQNKYLSSLDDASNSYPPTMQNIKQLVMSMIPSI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012214
EMBL· GenBank· DDBJ
BAO39167.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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