W0FW50 · W0FW50_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3367 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1501 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1525 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1585 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2524 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2554 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2555 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2572 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2573 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2599 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2600 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2686 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2905 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2909 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2914 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2917 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3179 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3195 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3314 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus denguei > Dengue virus
Accessions
- Primary accessionW0FW50
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-44 | Helical | ||||
Sequence: LVMAFIAFLRFLAIPPTAGILARW | ||||||
Transmembrane | 76-94 | Helical | ||||
Sequence: SVTMLLMLMPTALAFHLTT | ||||||
Transmembrane | 699-723 | Helical | ||||
Sequence: YGVLFSGVSWTMKIGIGVLLTWLGL | ||||||
Transmembrane | 729-748 | Helical | ||||
Sequence: SLSMTCIAVGLVTLYLGVMV | ||||||
Transmembrane | 1133-1152 | Helical | ||||
Sequence: MLMTGTLAVFFLLIMGQLTW | ||||||
Transmembrane | 1176-1196 | Helical | ||||
Sequence: YLALMATFKMRPMFAVGLLFR | ||||||
Transmembrane | 1269-1287 | Helical | ||||
Sequence: TMAMVLSIVSLFPLCLSTT | ||||||
Transmembrane | 1293-1312 | Helical | ||||
Sequence: WLPVLLGSLGCKPLTMFLIA | ||||||
Transmembrane | 1324-1342 | Helical | ||||
Sequence: LNEGIMAVGIVSILLSSLL | ||||||
Transmembrane | 1348-1365 | Helical | ||||
Sequence: LAGPLIAGGMLIACYVIS | ||||||
Transmembrane | 1417-1444 | Helical | ||||
Sequence: ILLKATLLAVSGVYPLSIPATLFVWYFW | ||||||
Transmembrane | 2124-2143 | Helical | ||||
Sequence: LMLLALIAVLTGGVTLFFLS | ||||||
Transmembrane | 2150-2167 | Helical | ||||
Sequence: TSIGLLCVMASSVLLWMA | ||||||
Transmembrane | 2173-2190 | Helical | ||||
Sequence: WIAASIILEFFLMVLLIP | ||||||
Transmembrane | 2202-2219 | Helical | ||||
Sequence: QLAYVVIGLLFMILTVAA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 258↔285 | |||||
Sequence: CVGIGSRDFVEGLSGATWVDVVLEHGSC | ||||||
Disulfide bond | 315↔371 | |||||
Sequence: CIEAKISNTTTDSRCPTQGEATLVEEQDANFVCRRTFVDRGWGNGCGLFGKGSLITC | ||||||
Disulfide bond | 329↔360 | |||||
Sequence: CPTQGEATLVEEQDANFVCRRTFVDRGWGNGC | ||||||
Disulfide bond | 347↔376 | |||||
Sequence: CRRTFVDRGWGNGCGLFGKGSLITCAKFKC | ||||||
Disulfide bond | 440↔540 | |||||
Sequence: CSPRTGLDFNEMVLLTMKEKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKC | ||||||
Disulfide bond | 557↔588 | |||||
Sequence: CTGSFKLEKEVAETQHGTVLVQIKYEGTDAPC |
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with serine protease NS3.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1321-1450 | Flavivirus NS2B | ||||
Sequence: SWPLNEGIMAVGIVSILLSSLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAVVSWEEEAEHSGASHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAVSGVYPLSIPATLFVWYFWQKKKQR | ||||||
Domain | 1451-1628 | Peptidase S7 | ||||
Sequence: SGVLWDTPSPPEVERAVLDDGIYRIMQRGLLGRSQVGVGVFQENVFHTMWHVTRGAVLMYQGKRLEPSWASVKKDLISYGGGWRLQGSWNTGEEVQVIAVEPGKNPKNVQTAPGTFKTSEGEVGAIALDFKPGTSGSPIVNREGKIVGLYGNGVVTTSGTYVSAIAQAKASQEGPLPE | ||||||
Domain | 1631-1787 | Helicase ATP-binding | ||||
Sequence: DEVFRKRNLTIMDLHPGSGKTRRYLPAIVREAIKRKLRTLILAPTRVVASEMAEALKGMPIRYQTTAVKSEHTGKEIVDLMCHATFTMRLLSPVRVPNYNMIIMDEAHFTDPSSIAARGYISTRVGMGEAAAIFMTATPPGSVEAFPQSNAVIQDEE | ||||||
Domain | 1797-1963 | Helicase C-terminal | ||||
Sequence: SGYEWITDFPGKTVWFVPSIKSGNDIANCLRKNGKRVIQLSRKTFDTEYQKTKNNDWDYVVTTDISEMGANFRADRVIDPRRCLKPVILKDGPERVILAGPMPVTVASAAQRRGRIGRNHNKEGDQYIYMGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPE | ||||||
Domain | 2470-2731 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: TGAQGETLGEKWKRQLNQLSKSEFNTYKRSGIMEVDRSEAKEGLKRGETTKHAVSRGTAKLRWFVERNLVKPEGKVIDLGCGRGGWSYYCAGLKKVTEVKGYTKGGPGHEEPIPMATYGWNLVKLHSGKDVFFIPPEKCDTLLCDIGESSPNPTIEEGRTLRVLKMVEPWLRGNQFCIKILNPYMPSVVETLEQMQRKHGGMLVRNPLSRNSTHEMYWVSCGTGNIVSAVNMTSRMLLNRFTMAHRKPTYERDVDLGAGTRH | ||||||
Domain | 2995-3144 | RdRp catalytic | ||||
Sequence: GNMYADDTAGWDTRITEDDLQNEAKITDIMEPEHALLAKSIFKLTYQNKVVRVQRPAKNGTVMDVISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMESEGIFSPSELETPNLAGRVLDWLEKHGVERLKRMAISGDDCVVKPIDDRFATA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length3,367
- Mass (Da)375,868
- Last updated2014-03-19 v1
- ChecksumC4EA37C992D5661C
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V |