W0FLJ6 · W0FLJ6_9BACT

Function

function

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Isomerase that catalyzes the conversion of deoxy-ribose 1-phosphate (dRib-1-P) and ribose 1-phosphate (Rib-1-P) to deoxy-ribose 5-phosphate (dRib-5-P) and ribose 5-phosphate (Rib-5-P), respectively.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions.

Pathway

Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2.
Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11Mn2+ 1 (UniProtKB | ChEBI)
Binding site294Mn2+ 2 (UniProtKB | ChEBI)
Binding site299Mn2+ 2 (UniProtKB | ChEBI)
Binding site335Mn2+ 1 (UniProtKB | ChEBI)
Binding site336Mn2+ 1 (UniProtKB | ChEBI)
Binding site347Mn2+ 2 (UniProtKB | ChEBI)
Active site491Proton donor/acceptor
Active site555Schiff-base intermediate with acetaldehyde
Active site584Proton donor/acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondeoxyribose-phosphate aldolase activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular Functionphosphopentomutase activity
Biological Process2-deoxyribose 1-phosphate catabolic process
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processcellular metabolic compound salvage
Biological Processdeoxyribonucleotide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Deoxyribose-phosphate aldolase
  • EC number
  • Short names
    DERA
  • Alternative names
    • 2-deoxy-D-ribose 5-phosphate aldolase
    • Phosphodeoxyriboaldolase
      (Deoxyriboaldolase
      )
  • Recommended name
    Phosphopentomutase
  • EC number
  • Alternative names
    • Phosphodeoxyribomutase

Gene names

    • Name
      deoC
    • Synonyms
      deoB

Organism names

Accessions

  • Primary accession
    W0FLJ6

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-384Metalloenzyme

Sequence similarities

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
Belongs to the phosphopentomutase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    65,770
  • Last updated
    2014-03-19 v1
  • Checksum
    49872CD062DC4B71
MAKRVFLIILDSLGCGNAPDASAFGDQGSNTLAAVLSASDKPFPNLSSMGLFDIDGNSDPRILEYLSKDPQAGRPAPIGAYGRLREESSGGKDSTIGHWEIAGVVSEDPQPTYPDGFPSYVVDKLKEISGRGVLCNLPYSGTQAIEDYGEEHFSSGDLILYTSADSVLQIAAHEEIVPLDELYRICREMRTFMTGKDAVGRIIARPFTGTPGSFTRTANRHDFAVEAPSATMMDHLKAKGFDVISVGKIYDLFAGRGFTETNPTKGNSEGIAKIREYLDKDFTGLLFSNLVDFDMLYGHRNNIEGYNEALHEFDDALGDILESLKEDDLLIISADHGCDPSTVSTDHSREQVPLLIYGKGYSTPRNLGSITGFSYISQVVVNALSGARFEKRFPERDLDPSDPGDVMTYVDLTNLKVTATEDDIKALIDRAIASKTMSVCIPPCYVRSAYDYARGRIPICTVIGFPNGYNTTSVKVTEAKDAVDNGACEIDMVINVAFVKAGKMKEVEDEVKAIAGAVHEKGAILKVIIEACLLTEEEKVALCGIVERCGAEYIKTSTGFSTGGATVEDVALMRANLSSSVRIKAAGGIRSPEAARAMIDAGATRIGASGL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC246771
EMBL· GenBank· DDBJ
AHF23687.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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