V9TVB2 · V9TVB2_MERS
- ProteinORF1ab polyprotein
- Geneorf1ab
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2685 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 1605 | ||||
Active site | 1607 | ||||
Active site | 1706 | ||||
Active site | 1783 | ||||
Active site | 1788 | ||||
Binding site | 1846-1852 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 2270 | ||||
Active site | 2285 | ||||
Active site | 2325 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell perinuclear region of cytoplasm | |
Cellular Component | membrane | |
Molecular Function | 3'-5'-RNA exonuclease activity | |
Molecular Function | 5'-3' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type peptidase activity | |
Molecular Function | endonuclease activity | |
Molecular Function | mRNA (nucleoside-2'-O-)-methyltransferase activity | |
Molecular Function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameORF1ab polyprotein
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Merbecovirus
Accessions
- Primary accessionV9TVB2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-246 | NiRAN | |||
Domain | 251-349 | Nsp12 Interface | |||
Domain | 350-917 | Nsp12 RNA-dependent RNA polymerase | |||
Domain | 597-759 | RdRp catalytic | |||
Domain | 918-1001 | CV ZBD | |||
Domain | 1174-1530 | +RNA virus helicase C-terminal | |||
Domain | 1587-1802 | ExoN | |||
Domain | 1811-2039 | N7-MTase | |||
Region | 1925-1939 | GpppA-binding | |||
Domain | 2040-2100 | Nsp15 N-terminal oligomerization | |||
Domain | 2101-2223 | AV-Nsp11N/CoV-Nsp15M | |||
Domain | 2240-2379 | NendoU | |||
Domain | 2384-2678 | Nidovirus-type SAM-dependent 2'-O-MTase | |||
Sequence similarities
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,685
- Mass (Da)303,219
- Last updated2014-03-19 v1
- Checksum7638CB81574474A1
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Keywords
- Coding sequence diversity
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF961222 EMBL· GenBank· DDBJ | AHC74097.1 EMBL· GenBank· DDBJ | Genomic RNA |