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V9R701 · V9R701_9RICK

  • Protein
    Orotate phosphoribosyltransferase
  • Gene
    pyrE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site121-1295-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site125orotate (UniProtKB | ChEBI)
Binding site153orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Biological Process'de novo' UMP biosynthetic process
Biological Processpyrimidine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • ORF names
      EMUR_04500

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AS154
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Anaplasmataceae > Ehrlichia

Accessions

  • Primary accession
    V9R701

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-170Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,737
  • Last updated
    2014-03-19 v1
  • MD5 Checksum
    86A2324F7DB3794CD9DDF3E7ED370C73
MEADLLNSDSIYDEFTKIGVIISGHFVLSSGLHSDTYVQCARLFENPVIAIRFCSLLAKKISTVLPNIDLIVSPAIGAITVGYEIARQLGVNSVFCERVNGLFTLRRGFEIKKGSKVLVMEDVITTGKTSMEVVNCVRKNGGTVVAGAALVKRSRDVKLPFPIISLIELNIKSYVDEDVPEYLRQIPVSIPGSRHLQE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006917
EMBL· GenBank· DDBJ
AHC39592.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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