V9K8I9 · V9K8I9_CALMI
- ProteinNeuropilin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids930 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | focal adhesion | |
Cellular Component | membrane | |
Molecular Function | heparin binding | |
Molecular Function | metal ion binding | |
Molecular Function | semaphorin receptor activity | |
Molecular Function | vascular endothelial growth factor binding | |
Molecular Function | vascular endothelial growth factor receptor activity | |
Biological Process | axon guidance | |
Biological Process | neural crest cell migration | |
Biological Process | positive regulation of endothelial cell migration | |
Biological Process | positive regulation of filopodium assembly | |
Biological Process | regulation of vascular endothelial growth factor receptor signaling pathway | |
Biological Process | response to wounding | |
Biological Process | sprouting angiogenesis | |
Biological Process | vascular endothelial growth factor receptor signaling pathway | |
Biological Process | vasculogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNeuropilin
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Holocephali > Chimaeriformes > Callorhinchidae > Callorhinchus
Accessions
- Primary accessionV9K8I9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 864-889 | Helical | ||||
Sequence: ILITIIAMSALGVILGAICGVVLYCA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MRKQRRTAALLHTLTVLIGLSGA | ||||||
Chain | PRO_5004778509 | 24-930 | Neuropilin | |||
Sequence: HRSDRCGDTIHITSPGYLSSPGYPNSYYPRESCAWTIQAPQPYQRIMINFNPHFDLEDRDCKYDYVEVRDGGDEKAALLGKFCGKIAPSPQISTGPLLFVKFVSDYETHGAGFSIRYEVFKTGPECSRNYTSQSAEIRSPGFPEKYPNNLECTYMIVAPVMAEILLEFGSFDLEPDSNLREGMLCRFDRLEIWDGFPGVGLHIGRFCGQVVPENIRSLTGILSLTLHTDTAIARDGFSANYSIIQKNLSENTHCNESLGMETGAIHSDQILTSSTYNLYWASERARLNYPENAWTPAEDSSKEWIQVDLGFLRQVSAIATQGAVSKETKKQYYIKSYKVDISSNGEDWITVKEKNKQKIFQGNSNPSEAVVRQFPQTVLTRYVRVRPLTWETGVALRFELYGCKFTDRPCSGMLGMVSGLISDNQVTASSTVDRYWAPEHARLLTSRSGWALQSASRPYNNEWLQIDLGVEKEVRSLIIQGAKQRENKVYMRKFKLAYSTNGSDWKMVSNPGSMKPKTFEGNSNYDTPEIRKFEPMLTRYIRVYPERASPAGLGLRMELLGCDIEVPTFPPTLDSDECDEDLGNCHSGTGDGFEFTDGNTALGTEEPTLPESPAFPDAIFPYEDNLNGFNCKFGSGVGKNFCNWRHDKATNFLWKVNSREGEADSRVPNLEKDHFIFTEIIGQEDGQVARLLSPPLLPVHHGHCLVFWYQIRGTHGSRLNVIQRKISDGFMNDVLWSLNGPQENRWQEGRVLLPQSPSMYQVGFEVMVRKGKQGEVAVHDVEVVSNRNANECMAPRNAFPGLVDGPTSVFPTVDDPEDPTNDSVGGSSGGPGNVLKTLDPILITIIAMSALGVILGAICGVVLYCACWHSALSDRNLSALENYNFELVDGVKLKKDKLSTQNSYSEA | ||||||
Disulfide bond | 29↔56 | |||||
Sequence: CGDTIHITSPGYLSSPGYPNSYYPRESC | ||||||
Disulfide bond | 84↔106 | |||||
Sequence: CKYDYVEVRDGGDEKAALLGKFC | ||||||
Disulfide bond | 149↔175 | |||||
Sequence: CSRNYTSQSAEIRSPGFPEKYPNNLEC | ||||||
Disulfide bond | 208↔230 | |||||
Sequence: CRFDRLEIWDGFPGVGLHIGRFC | ||||||
Disulfide bond | 277↔426 | |||||
Sequence: CNESLGMETGAIHSDQILTSSTYNLYWASERARLNYPENAWTPAEDSSKEWIQVDLGFLRQVSAIATQGAVSKETKKQYYIKSYKVDISSNGEDWITVKEKNKQKIFQGNSNPSEAVVRQFPQTVLTRYVRVRPLTWETGVALRFELYGC | ||||||
Disulfide bond | 433↔585 | |||||
Sequence: CSGMLGMVSGLISDNQVTASSTVDRYWAPEHARLLTSRSGWALQSASRPYNNEWLQIDLGVEKEVRSLIIQGAKQRENKVYMRKFKLAYSTNGSDWKMVSNPGSMKPKTFEGNSNYDTPEIRKFEPMLTRYIRVYPERASPAGLGLRMELLGC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-143 | CUB | ||||
Sequence: CGDTIHITSPGYLSSPGYPNSYYPRESCAWTIQAPQPYQRIMINFNPHFDLEDRDCKYDYVEVRDGGDEKAALLGKFCGKIAPSPQISTGPLLFVKFVSDYETHGAGFSIRYEVF | ||||||
Domain | 149-267 | CUB | ||||
Sequence: CSRNYTSQSAEIRSPGFPEKYPNNLECTYMIVAPVMAEILLEFGSFDLEPDSNLREGMLCRFDRLEIWDGFPGVGLHIGRFCGQVVPENIRSLTGILSLTLHTDTAIARDGFSANYSII | ||||||
Domain | 277-426 | F5/8 type C | ||||
Sequence: CNESLGMETGAIHSDQILTSSTYNLYWASERARLNYPENAWTPAEDSSKEWIQVDLGFLRQVSAIATQGAVSKETKKQYYIKSYKVDISSNGEDWITVKEKNKQKIFQGNSNPSEAVVRQFPQTVLTRYVRVRPLTWETGVALRFELYGC | ||||||
Domain | 433-585 | F5/8 type C | ||||
Sequence: CSGMLGMVSGLISDNQVTASSTVDRYWAPEHARLLTSRSGWALQSASRPYNNEWLQIDLGVEKEVRSLIIQGAKQRENKVYMRKFKLAYSTNGSDWKMVSNPGSMKPKTFEGNSNYDTPEIRKFEPMLTRYIRVYPERASPAGLGLRMELLGC | ||||||
Domain | 652-817 | MAM | ||||
Sequence: FNCKFGSGVGKNFCNWRHDKATNFLWKVNSREGEADSRVPNLEKDHFIFTEIIGQEDGQVARLLSPPLLPVHHGHCLVFWYQIRGTHGSRLNVIQRKISDGFMNDVLWSLNGPQENRWQEGRVLLPQSPSMYQVGFEVMVRKGKQGEVAVHDVEVVSNRNANECMA | ||||||
Region | 831-854 | Disordered | ||||
Sequence: SVFPTVDDPEDPTNDSVGGSSGGP |
Sequence similarities
Belongs to the neuropilin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length930
- Mass (Da)103,875
- Last updated2014-03-19 v1
- Checksum0F9D0AB95488F15A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JW861885 EMBL· GenBank· DDBJ | AFO94402.1 EMBL· GenBank· DDBJ | mRNA |