V9HW22 · V9HW22_HUMAN

  • Protein
    Heat shock cognate 71 kDa protein
  • Gene
    HEL-S-72p
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentautophagosome
Cellular Componentcell surface
Cellular Componentdendritic shaft
Cellular Componentdendritic spine
Cellular Componentextracellular exosome
Cellular Componentglutamatergic synapse
Cellular Componentglycinergic synapse
Cellular Componentintermediate filament
Cellular Componentlate endosome
Cellular Componentlysosomal matrix
Cellular Componentlysosomal membrane
Cellular Componentmicrotubule
Cellular Componentperikaryon
Cellular Componentperinuclear region of cytoplasm
Cellular Componentphotoreceptor inner segment
Cellular Componentphotoreceptor ribbon synapse
Cellular Componentpostsynaptic cytosol
Cellular Componentpostsynaptic density
Cellular Componentpostsynaptic specialization membrane
Cellular Componentpresynaptic cytosol
Cellular Componentspliceosomal complex
Cellular Componentsynaptic vesicle
Cellular Componentterminal bouton
Molecular FunctionA1 adenosine receptor binding
Molecular FunctionADP binding
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent protein folding chaperone
Molecular Functionclathrin-uncoating ATPase activity
Molecular Functionenzyme binding
Molecular Functionpeptide binding
Molecular Functionphosphatidylserine binding
Molecular Functionprostaglandin binding
Molecular FunctionRNA binding
Molecular Functionunfolded protein binding
Biological Processcellular response to cadmium ion
Biological Processcellular response to heat
Biological Processcellular response to hydrogen peroxide
Biological Processcerebellum development
Biological Processchaperone cofactor-dependent protein refolding
Biological Processchaperone-mediated autophagy translocation complex disassembly
Biological Processestrous cycle
Biological Processforebrain development
Biological ProcessG1/S transition of mitotic cell cycle
Biological Processkidney development
Biological Processlate endosomal microautophagy
Biological Processmaintenance of postsynaptic specialization structure
Biological ProcessmRNA processing
Biological Processnegative regulation of cardiac muscle cell apoptotic process
Biological Processpositive regulation by host of viral genome replication
Biological Processpositive regulation of lysosomal membrane permeability
Biological Processpositive regulation of mRNA splicing, via spliceosome
Biological Processpositive regulation of phagocytosis
Biological Processpositive regulation of protein refolding
Biological Processpositive regulation of proteolysis
Biological Processpositive regulation of T cell mediated cytotoxicity
Biological Processprotein import into nucleus
Biological Processprotein targeting to lysosome involved in chaperone-mediated autophagy
Biological Processprotein transmembrane import into intracellular organelle
Biological Processregulation of cell cycle
Biological Processregulation of postsynapse organization
Biological Processregulation of protein complex stability
Biological Processresponse to activity
Biological Processresponse to estradiol
Biological Processresponse to ethanol
Biological Processresponse to nickel cation
Biological Processresponse to odorant
Biological Processresponse to progesterone
Biological Processresponse to starvation
Biological Processresponse to xenobiotic stimulus
Biological ProcessRNA splicing
Biological Processskeletal muscle tissue development
Biological Processslow axonal transport
Biological Processsynaptic vesicle uncoating

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heat shock cognate 71 kDa protein
  • EC number
  • Alternative names
    • Heat shock 70 kDa protein 8

Gene names

    • Name
      HEL-S-72p
    • Synonyms
      HEL-33
      , HSPA8
    • ORF names
      hCG_2032950

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    V9HW22

Organism-specific databases

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region614-646Disordered

Sequence similarities

Belongs to the heat shock protein 70 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    646
  • Mass (Da)
    70,898
  • Last updated
    2014-03-19 v1
  • Checksum
    9AA27B210730670C
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU668349
EMBL· GenBank· DDBJ
ACF94502.1
EMBL· GenBank· DDBJ
mRNA
FJ224294
EMBL· GenBank· DDBJ
ACI45986.1
EMBL· GenBank· DDBJ
mRNA
GQ891324
EMBL· GenBank· DDBJ
ADO22186.1
EMBL· GenBank· DDBJ
mRNA
GQ891398
EMBL· GenBank· DDBJ
ADO22260.1
EMBL· GenBank· DDBJ
mRNA
CH471065
EMBL· GenBank· DDBJ
EAW67539.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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