V6TX84 · V6TX84_GIAIN

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      GSB_6427

Organism names

Accessions

  • Primary accession
    V6TX84

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-55Helical
Transmembrane75-97Helical
Transmembrane104-122Helical
Transmembrane128-148Helical
Transmembrane160-190Helical
Transmembrane202-222Helical
Transmembrane330-357Helical
Transmembrane377-397Helical
Transmembrane404-422Helical
Transmembrane428-449Helical
Transmembrane456-478Helical
Transmembrane498-516Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-521Major facilitator superfamily (MFS) profile

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    530
  • Mass (Da)
    56,765
  • Last updated
    2014-02-19 v1
  • MD5 Checksum
    A110AA5124EDBB22DBCF65DD5A381657
VGATKIYRQSKLFSLARIRMPKSDGARQCRAISIYIIAALIYIVVFFHRLVAASIGDEFQNRFGGSTNMSLDEMLGTFGSLYFYFYAFLQPFVGIIVDAIKPRWTIFTAGILMTGGSVIIAFPRQLAVVYFGRSLVGIGAAFVYVPILKLIALWFPIHRFALLTGIMVALGGLGGFVCTAPLTILIQTIATNAAAKDLIFEYIFGIVGGITALLTLIFVCVAHDTPEKAGYAPIVNQSTSQSEAASTGPAVQNDTVPTTGPTVAEGSLVSSGVVNIPDSAHDFYCNTAAPTFEILEPATKSATASLAKKSRMAEFCDSMKIVFCSENSKYLILMMVAYFFCVGSYFTISATAGVQLITNTVTSGGTSVKLEATWVQAGLNLGTIVGSPLQSVLANLMGRKPMQLINNGIMFLVYLGIAIAKIVNPAIWSYAILYVLIGLVGGTMIVVAYTNVKEMFPIAVSGTAIGFFNIAPFLGAAVFQNVSPLLIKLNGGNKYENMCYLLAANTAVAACVVIFSKETRAVKSRKQKRT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AHHH01000057
EMBL· GenBank· DDBJ
ESU43179.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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