V6T8V6 · V6T8V6_GIAIN

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      DHA2_9046

Organism names

Accessions

  • Primary accession
    V6T8V6

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane47-69Helical
Transmembrane76-98Helical
Transmembrane104-125Helical
Transmembrane132-153Helical
Transmembrane165-187Helical
Transmembrane225-247Helical
Transmembrane259-278Helical
Transmembrane290-308Helical
Transmembrane320-339Helical
Transmembrane346-365Helical
Transmembrane385-403Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-408Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    445
  • Mass (Da)
    48,021
  • Last updated
    2014-02-19 v1
  • MD5 Checksum
    8A987B2099D36BAE933A9A3CDA4D909A
MAASARQGIITITFCSLAYMFSYIHRICITSITDLMQGVYAVELDKIGILVSTFFYTYSALQPFAGLAVDILQARWVVFVSGFLVAAGSILMGCIVNFPAACAFRGLAGIGSACLYVATVKYAMLWLAPKQFVICTGSLAASSGLASLLASAPLRHLADAIGIRLLFVILGVCPLIASIIVGIVGSYPPLYYASGKQTTKDAIKDFKNGFRELGRTRAAVSLIPLLIYYFFFSGANYTISAFLGVVFITSLNQSLSHTYATWMFLLQSIGLIISGLAIPHVAKYIGRKPPHIITPLLVSGLMFCIAFFKEQAAGWKFGMVYFFYGILTGATVPIGYTLCKELVPPDILATAIGLFNFFPALGGAIFQNTFPLLLRTNSLTEYQTIAFILAGQYLLCAFIGAFLKETSGLTIGRTCKRPQRRSAISDNNAGADGKEIQMNSTQISA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AHGT01000088
EMBL· GenBank· DDBJ
ESU35318.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help